| Full text | |
| Author(s): |
Vattimo, Edoardo F. Q.
[1]
;
Barros, Vivian B.
[2]
;
Requena, Guaraci
[3]
;
Sato, Joao R.
[4]
;
Fatori, Daniel
[1]
;
Miguel, Euripedes C.
[5]
;
Shavitt, Roseli G.
[1]
;
Hoexter, Marcelo Q.
[5]
;
Batistuzzo, Marcelo C.
[5]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Dept & Inst Psychiat, Hosp Clin HCFMUSP, Fac Med, R Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Stat, Inst Math & Stat, Sao Paulo, SP - Brazil
[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[5] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | EUROPEAN CHILD & ADOLESCENT PSYCHIATRY; v. 28, n. 12, p. 1607-1617, DEC 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Treatment response in obsessive-compulsive disorder (OCD) is heterogeneous and the neurobiological underpinnings of such variability are unknown. To investigate this issue, we looked for differences in brain structures possibly associated with treatment response in children with OCD. 29 children with OCD (7-17 years) and 28 age-matched controls underwent structural magnetic resonance imaging. Patients then received treatment with fluoxetine or group cognitive-behavioral therapy during 14 weeks, and were classified as treatment responders or non-responders. The caudate nucleus, thalamus and orbitofrontal cortex were selected a priori, according to previous evidence of their association with OCD and its treatment. Gray matter (GM) volume comparisons between responders, non-responders and controls were performed, controlling for total GM volume. 17 patients were classified as responders. Differences among responders, non-responders and controls were found in both caudate nuclei (both p-values=0.041), but after Bonferroni correction for multiple comparisons, these findings were non-significant. However, after excluding the effect of an outlier, findings were significant for the right caudate (p=0.004). Pairwise comparisons showed larger caudate GM volume in responders versus non-responders and controls, bilaterally. The right caudate accounted for 20.2% of the variance in Y-BOCS changes after treatment in a linear regression model, with a positive correlation (p=0.016). We present a possible neural substrate for treatment response in pediatric OCD, which is in line with previous evidence regarding the caudate nucleus. Considering the limitations, further research is needed to replicate this finding and elucidate the heterogeneity of treatment response in children with OCD. (AU) | |
| FAPESP's process: | 13/08531-5 - High Risk Cohort Study for Psychiatric Disorders in Childhood: 3-year follow-up neuroimaging study |
| Grantee: | Andrea Parolin Jackowski |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/21934-5 - Network statistics: theory, methods, and applications. |
| Grantee: | André Fujita |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/04654-9 - Time Series, Wavelets and High Dimensional Data |
| Grantee: | Pedro Alberto Morettin |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/50917-0 - Inct 2014 - psiquiatria do desenvolvimento para criancas e adolescentes. |
| Grantee: | Eurípedes Constantino Miguel Filho |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 09/09949-8 - Episodic verbal memory associated with brain activation in obsessive-compulsive disorder (OCD): functional magnetic resonance imaging analysis. |
| Grantee: | Marcelo Camargo Batistuzzo |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |