Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and prospects

Autor(es)

Tellez-Martinez, Damiana ^[1] ; Batista-Duharte, Alexander ^[1] ; Portuondo, Deivys Leandro ^[1] ; Carlos, Iracilda Zeppone ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Rodovia Araraquara Jai Km 1, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Microbes and Infection; v. 21, n. 10, p. 432-440, DEC 2019.
• Citações Web of Science: 0

Resumo

Sporotrichosis is an emergent subcutaneous mycosis of humans and some animals caused by dimorphic fungi of the genus Sporothrix. The disease occurs worldwide but is endemic or hyperendemic in tropical and subtropical areas. The epidemiology of the disease is changing dramatically, and it is now considered an important zoonosis with high morbidity rates, principally in Brazil, and an opportunistic infection in immunocompromised patients. Due to the limited options currently available to treat invasive fungal infections, including sporotrichosis, and the emergence of drug resistance and toxicity, the development of anti-Sporothrix vaccines has become an area of great interest. This work provides a brief analysis of the feasibility of the development of prophylactic and therapeutic vaccines against sporotrichosis, the main advances achieved to date, future challenges and prospects. (C) 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 17/26774-3 - Imunogenicidade e eficácia pré-clinica de um candidato vacinal de enolase recombinante contra Sporothrix schenckii e Sporothrix brasiliensis
• Beneficiário: Iracilda Zeppone Carlos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/04250-0 - Papel das células t reguladoras CD4+CD25+FOXP3+ na resposta imune contra Sporothrix schenckii após infecção e vacinação
• Beneficiário: Alexander Batista Duharte
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado