Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and prospects

Author(s)

Tellez-Martinez, Damiana ^[1] ; Batista-Duharte, Alexander ^[1] ; Portuondo, Deivys Leandro ^[1] ; Carlos, Iracilda Zeppone ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Rodovia Araraquara Jai Km 1, BR-14800903 Araraquara, SP - Brazil

• Document type: Review article
• Source: Microbes and Infection; v. 21, n. 10, p. 432-440, DEC 2019.
• Web of Science Citations: 0

Abstract

Sporotrichosis is an emergent subcutaneous mycosis of humans and some animals caused by dimorphic fungi of the genus Sporothrix. The disease occurs worldwide but is endemic or hyperendemic in tropical and subtropical areas. The epidemiology of the disease is changing dramatically, and it is now considered an important zoonosis with high morbidity rates, principally in Brazil, and an opportunistic infection in immunocompromised patients. Due to the limited options currently available to treat invasive fungal infections, including sporotrichosis, and the emergence of drug resistance and toxicity, the development of anti-Sporothrix vaccines has become an area of great interest. This work provides a brief analysis of the feasibility of the development of prophylactic and therapeutic vaccines against sporotrichosis, the main advances achieved to date, future challenges and prospects. (C) 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. (AU)

• FAPESP's process: 17/26774-3 - Immunogenicity and preclinical efficacy of a recombinant enolase vaccine candidate against Sporothrix schenckii and Sporothrix brasiliensis
• Grantee: Iracilda Zeppone Carlos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/04250-0 - Role of CD4+CD25+FoxP3+ Regulatory T cells in the post-infection and post-vaccination immune response to Sporothrix schenckii
• Grantee: Alexander Batista Duharte
• Support Opportunities: Scholarships in Brazil - Post-Doctoral