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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis

Texto completo
Autor(es):
dos Santos, Alexandre Moura [1] ; Misse, Rafael Giovani [1] ; Pires Borges, Isabela Bruna [1] ; Shinjo, Samuel Katsuyuki [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Av Dr Arnaldo, 455, 3 Andar, Sala 3150, BR-01246903 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: ADVANCES IN RHEUMATOLOGY; v. 60, n. 1 DEC 31 2019.
Citações Web of Science: 0
Resumo

Background This study was aimed at evaluating the aerobic capacity of patients with antisynthetase syndrome (ASS) and dermatomyositis (DM) and analyzing possible relationships between aerobic capacity and disease status, cardiovascular diseases and their risk factors. Methods The study was a cross-sectional, single-center study that assessed the aerobic capacity of 22 women (13 with DM and 9 with ASS) who were matched by age and body mass index to 17 healthy women (control group). The aerobic capacity (oxygen uptake {[}VO2 peak], anaerobic threshold, respiratory compensation point and time-to-exhaustion) was evaluated using the cardiopulmonary treadmill test. Disease status was assessed using International Myositis Assessment \& Clinical Studies Group (IMACS) set scores. Results The patients had low IMACS parameters that showed low or absent disease activity. The distribution of cardiovascular diseases and their risk factors was similar between the patients and the control group (P > 0.05) at the time of the analysis. The patients with DM and the control group had similar aerobic capacity. However, the patients with ASS exhibited significantly reduced aerobic capacity (relative VO2 peak, anaerobic threshold, respiratory compensation point and time to exhaustion) when compared to the control group. In addition, patients with ASS had a lower anaerobic threshold compared to the DM group. There were no significant relationships between the aerobic capacity and disease status, cardiovascular diseases and their risk factors. Conclusion In contrast to DM patients and healthy individuals, patients with stable ASS have significantly impaired aerobic capacity, which is unlikely to be totally explained by traditional cardiovascular diseases, their risk factors and disease status. Further studies are needed to corroborate our data and to clarify the cause of this reduced aerobic capacity in ASS. (AU)

Processo FAPESP: 17/13109-1 - Impacto do treinamento físico na resistência a ação da insulina, conteúdo lipídico, angiogênese e fibrogênese do músculo esquelético de pacientes com miopatias inflamatórias idiopáticas
Beneficiário:Samuel Katsuyuki Shinjo
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/23574-0 - Efeitos do treinamento físico na função endotelial e nas propriedades funcionais de grandes artérias de pacientes com miopatias inflamatórias idiopáticas: Ensaio clínico controlado e randomizado
Beneficiário:Rafael Giovani Misse
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 18/08735-3 - Capacidade aeróbia e exercício de força na arterite de Takayasu: relações e impactos nos desfechos clínicos, laboratoriais e extensão das lesões vasculares
Beneficiário:Alexandre Moura dos Santos
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 16/20371-1 - Efeito do uso de hipolipemiantes na função endotelial e na rigidez vascular de pacientes com dermatomiosite e polimiosite: estudo prospectivo, duplo cego, randomizado e controlado
Beneficiário:Isabela Bruna Pires Borges
Linha de fomento: Bolsas no Brasil - Mestrado