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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis

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Author(s):
dos Santos, Alexandre Moura [1] ; Misse, Rafael Giovani [1] ; Pires Borges, Isabela Bruna [1] ; Shinjo, Samuel Katsuyuki [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Av Dr Arnaldo, 455, 3 Andar, Sala 3150, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ADVANCES IN RHEUMATOLOGY; v. 60, n. 1 DEC 31 2019.
Web of Science Citations: 0
Abstract

Background This study was aimed at evaluating the aerobic capacity of patients with antisynthetase syndrome (ASS) and dermatomyositis (DM) and analyzing possible relationships between aerobic capacity and disease status, cardiovascular diseases and their risk factors. Methods The study was a cross-sectional, single-center study that assessed the aerobic capacity of 22 women (13 with DM and 9 with ASS) who were matched by age and body mass index to 17 healthy women (control group). The aerobic capacity (oxygen uptake {[}VO2 peak], anaerobic threshold, respiratory compensation point and time-to-exhaustion) was evaluated using the cardiopulmonary treadmill test. Disease status was assessed using International Myositis Assessment \& Clinical Studies Group (IMACS) set scores. Results The patients had low IMACS parameters that showed low or absent disease activity. The distribution of cardiovascular diseases and their risk factors was similar between the patients and the control group (P > 0.05) at the time of the analysis. The patients with DM and the control group had similar aerobic capacity. However, the patients with ASS exhibited significantly reduced aerobic capacity (relative VO2 peak, anaerobic threshold, respiratory compensation point and time to exhaustion) when compared to the control group. In addition, patients with ASS had a lower anaerobic threshold compared to the DM group. There were no significant relationships between the aerobic capacity and disease status, cardiovascular diseases and their risk factors. Conclusion In contrast to DM patients and healthy individuals, patients with stable ASS have significantly impaired aerobic capacity, which is unlikely to be totally explained by traditional cardiovascular diseases, their risk factors and disease status. Further studies are needed to corroborate our data and to clarify the cause of this reduced aerobic capacity in ASS. (AU)

FAPESP's process: 17/13109-1 - Impact of physical training on resistance to insulin action, lipid content, angiogenesis and fibrogenesis of skeletal muscle in patients with idiopathic inflammatory myopathies
Grantee:Samuel Katsuyuki Shinjo
Support type: Regular Research Grants
FAPESP's process: 16/23574-0 - Effects of physical training in endothelial function and functional properties of large arteries in patients with idiopathic inflammatory myopathies: A randomized controlled trial
Grantee:Rafael Giovani Misse
Support type: Scholarships in Brazil - Master
FAPESP's process: 18/08735-3 - Aerobic capacity and strength exercise in Takayasu's arteritis: relationships and impacts on clinical, laboratory and vascular end points
Grantee:Alexandre Moura dos Santos
Support type: Scholarships in Brazil - Master
FAPESP's process: 16/20371-1 - Effect of lipid-lowering drugs on endothelial function and vascular stiffness in patients with dermatomyositis and polymyositis: a prospective, double-blind, randomized controlled trial
Grantee:Isabela Bruna Pires Borges
Support type: Scholarships in Brazil - Master