Origin of the Sao Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases

Autor(es):Mostrar menos -

Cunha, Marielton dos Passos ^[1] ; Duarte-Neto, Amaro Nunes ^[2] ; Pour, Shahab Zaki ^[1] ; Ortiz-Baez, Ayda Susana ^{[3, 1, 4]} ; Cerny, Jiri ^[5] ; de Souza Pereira, Barbara Brito ^[1] ; Braconi, Carla Torres ^[1] ; Ho, Yeh-Li ^[6] ; Perondi, Beatriz ^[7] ; Sztajnbok, Jaques ^[8] ; Ferreira Alves, Venancio Avancini ^[2] ; Dolhnikoff, Marisa ^[2] ; Holmes, Edward C. ^{[3, 9]} ; Nascimento Saldiva, Paulo Hilario ^[2] ; de Andrade Zanotto, Paolo Marinho ^{[1, 10]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Clin Hosp, Fac Med, Pathol Dept, Sao Paulo - Brazil

^[3] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006 - Australia

^[4] Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006 - Australia

^[5] Czech Univ Life Sci Prague, Fac Trop AgriSci, Prague - Czech Republic

^[6] Univ Sao Paulo, Clin Hosp, Fac Med, Intens Care Unit, Div Clin Infect & Parasit Dis, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Clin Hosp, Fac Med, Yellow Fever Crisis Comm, Sao Paulo - Brazil

^[8] Inst Infectol Emilio Ribas, Sao Paulo - Brazil

^[9] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW - Australia

^[10] Sci Platform Pasteur USP, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 9, DEC 31 2019.
• Citações Web of Science: 0

Resumo

The largest outbreak of yellow fever of the 21st century in the Americas began in 2016, with intense circulation in the southeastern states of Brazil, particularly in sylvatic environments near densely populated areas including the metropolitan region of Sao Paulo city (MRSP) during 2017-2018. Herein, we describe the origin and molecular epidemiology of yellow fever virus (YFV) during this outbreak inferred from 36 full genome sequences taken from individuals who died following infection with zoonotic YFV. Our analysis revealed that these deaths were due to three genetic variants of sylvatic YFV that belong the South American I genotype and that were related to viruses previously isolated in 2017 from other locations in Brazil (Minas Gerais, Espirito Santo, Bahia and Rio de Janeiro states). Each variant represented an independent virus introduction into the MRSP. Phylogeographic and geopositioning analyses suggested that the virus moved around the peri-urban area without detectable human-to-human transmission, and towards the Atlantic rain forest causing human spill-over in nearby cities, yet in the absence of sustained viral transmission in the urban environment. (AU)

• Processo FAPESP: 17/23281-6 - Utilização de anticorpos que neutralizam a infecção após a adesão à célula para o desenvolvimento de estratégias imunoterápicas inovadoras exemplificadas pela destruição seletiva de células humanas infectadas pelo vírus Zika.
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/25434-3 - Diversidade genética intra-hospedeiro do vírus da dengue tipo 4 no município de Guarujá, Estado de São Paulo
• Beneficiário: Ayda Susana Ortiz Baez
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/21728-2 - Uso de modernas técnicas de autópsia na investigação de doenças humanas (MODAU)
• Beneficiário: Paulo Hilário Nascimento Saldiva
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/08204-2 - Diversidade genética e filodinâmica dos arbovírus emergentes e reemergentes (DENV, ZIKV e CHIKV) nas regiões Nordeste e Sudeste do Brasil, 2014-2016
• Beneficiário: Marielton dos Passos Cunha
• Modalidade de apoio: Bolsas no Brasil - Doutorado