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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Food safety evaluation for the use of albendazole in fish: residual depletion profile and withdrawal period estimation

Texto completo
Autor(es):
Vellosa Portela, Ana Carolina [1] ; Fernandes Silveira, Juliana Grell [1] ; Damaceno, Marina Alves [1] ; Baldo da Silva, Agnaldo Fernando [1] ; de Jesus, Raphael Barbetta [2] ; Pilarski, Fabiana [2] ; Gadaj, Anna [3] ; Mooney, Mark H. [3] ; Rizzato Paschoal, Jonas Augusto [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Ribeirao Preto, SP - Brazil
[2] Univ Estadual Paulista Unesp, Ctr Aquicultura Unesp, Jaboticabal - Brazil
[3] Queens Univ Belfast, Inst Global Food Secur, Sch Biol Sci, Belfast, Antrim - North Ireland
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure; v. 37, n. 4 FEB 2020.
Citações Web of Science: 0
Resumo

Due to the lack of drugs regulated for aquaculture, we have evaluated the use of albendazole (ABZ) - a potential drug to be regulated for fish - under food safety perspectives assessing the depletion profile of ABZ and its main metabolites (albendazole sulphoxide - ABZSO, albendazole sulphone - ABZSO(2) and albendazole amino sulphone - ABZ-2-NH2SO2) in fish fillets (muscle and skin) after single dose oral administration of 10 mg ABZ kg(-1) body weight. For the drug administration, a suitable procedure for ABZ incorporation into fish feed was employed, obtaining good homogeneity of ABZ concentration among feed pellets (CV<4.1%) and low drug leaching when medicated feed remained in the water for up to 60 min (<2.7%). After medication, fish were euthanised at 8, 12, 24, 48, 72, 96 and 120 h and fillets collected. Depletion studies in various fish species (patinga and tilapia) were conducted simultaneously, under water temperature at 30.4 +/- 0.3 degrees C and pH 6.8 +/- 0.1. The highest concentrations for the sum of residues (ABZ, ABZSO, ABZSO(2) and ABZ-2-NH2SO2) in fish fillet were 1210 ng g(-1) in patinga and 637 ng g(-1) in tilapia. Under the employed rearing conditions, the obtained results did not indicate a requirement for a minimum withdrawal period to be proposed for tilapia considering the maximum residue limit of 100 mu g g(-1), since the determined residual concentration was <LOQ (10 ng g(-1)) from 24 h post medication treatment. For patinga, the estimated minimum withdrawal period was 3 days. With the well-recognised demands for new alternative veterinary drugs for aquaculture use by fish farmers, this study offers important evidence for consideration of ABZ use in tilapia and patinga taking into account food safety issues. (AU)

Processo FAPESP: 12/18334-0 - Resíduos de medicamentos veterinários em alimentos: métodos analíticos multiclasses empregando LC-MS/MS, dados de exposição e estudos de depleção residual
Beneficiário:Jonas Augusto Rizzato Paschoal
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 16/16593-9 - Estimativa e avaliação dos períodos de carência do albendazol e metabólitos em peixes
Beneficiário:Ana Carolina Vellosa Portela
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/50755-0 - Metaqua: metabolite/metabolomic profiling in aquaculture research with a view to maintaining food safety / security and animal / human health
Beneficiário:Jonas Augusto Rizzato Paschoal
Linha de fomento: Auxílio à Pesquisa - Regular