Double-edged sword of inflammasome genetics in colorectal cancer prognosis

Autor(es)

Goncalves Cambui, Raylane Adrielle ^{[1, 2]} ; do Espirito Santo, Gilmar Ferreira ^[3] ; Fernandes, Fernanda Pereira ^[1] ; Cordeiro Leal, Vinicius Nunes ^[1] ; Galera, Bianca Borsatto ^[2] ; Palacio Favaro, Emerson Giuliano ^[4] ; Rizzo, Leonardo Amorim ^[5] ; Elias, Rosa Maria ^[5] ; Pontillo, Alessandra ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, SP - Brazil

^[2] Univ Fed Mato Grosso, Fac Med, Cuiaba, MT - Brazil

^[3] Hosp Geral & Maternidade Cuiaba, Inst Tumores & Cuidados Paliat Cuiaba, Cuiaba, MT - Brazil

^[4] Univ Cuiaba, Cuiaba, MT - Brazil

^[5] Ctr Univ Varzea Grande, Varzea Grande, MT - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinical Immunology; v. 213, APR 2020.
• Citações Web of Science: 0

Resumo

Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1 beta and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers. (AU)

• Processo FAPESP: 15/50650-7 - Caracterização de novos alvos moleculares no controle da obesidade e da inflamação induzida pela obesidade
• Beneficiário: Alessandra Pontillo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/23395-6 - Imunogenetica do inflamassoma, estudo translacional "da clinica a bancada,da bancada a clinica":analise das variações nos genes do inflamassoma em doenças autoinflamatorias monogênicas e multifatoriais para diagnostico diferencial e aplicações terapêutica
• Beneficiário: Alessandra Pontillo
• Modalidade de apoio: Auxílio à Pesquisa - Regular