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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Double-edged sword of inflammasome genetics in colorectal cancer prognosis

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Author(s):
Goncalves Cambui, Raylane Adrielle [1, 2] ; do Espirito Santo, Gilmar Ferreira [3] ; Fernandes, Fernanda Pereira [1] ; Cordeiro Leal, Vinicius Nunes [1] ; Galera, Bianca Borsatto [2] ; Palacio Favaro, Emerson Giuliano [4] ; Rizzo, Leonardo Amorim [5] ; Elias, Rosa Maria [5] ; Pontillo, Alessandra [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, SP - Brazil
[2] Univ Fed Mato Grosso, Fac Med, Cuiaba, MT - Brazil
[3] Hosp Geral & Maternidade Cuiaba, Inst Tumores & Cuidados Paliat Cuiaba, Cuiaba, MT - Brazil
[4] Univ Cuiaba, Cuiaba, MT - Brazil
[5] Ctr Univ Varzea Grande, Varzea Grande, MT - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Clinical Immunology; v. 213, APR 2020.
Web of Science Citations: 0
Abstract

Inflammation is a colorectal cancer (CRC) hallmark. Inflammasome-dependent cytokines IL-1 beta and IL-18 can play a beneficial or detrimental role in tumorigenesis depending on cancer type. Variants in inflammasome genes were associated with tumor development and/or outcome, and have been proposed as potential biomarkers for population screening. In this study, 215 CRC patients followed-up for 10 years were examined for 9 polymorphisms in selected inflammasome genes. Multivariate association analysis and survival analysis were performed to evaluate the association between the polymorphisms and CRC prognosis. Variants associated with lower levels of IL-18 (rs1834481, rs5744256), or with increased activation of inflammasome receptors NLRP1 (rs12150220) and NLRP3 (rs35829419) resulted detrimental to CRC prognosis and may be used as prognostic markers. (AU)

FAPESP's process: 15/50650-7 - Characterization of novel molecular players in the control of obesity and obesity-induced inflammation
Grantee:Alessandra Pontillo
Support Opportunities: Regular Research Grants
FAPESP's process: 15/23395-6 - Immunogenetics of the inflammasome and translational study "from bed to bench and back": analysis of variations in inflammasome genes in monogenic and multifactorial autoinflammatory diseases for differential diagnosis and therapeutic applications
Grantee:Alessandra Pontillo
Support Opportunities: Regular Research Grants