CandidaBiofilms: An Update on Developmental Mechanisms and Therapeutic Challenges

Autor(es)

de Barros, Patricia Pimentel ^[1] ; Rossoni, Rodnei Dennis ^[1] ; de Souza, Cheyenne Marcal ^[1] ; Scorzoni, Liliana ^[1] ; Fenley, Juliana De Camargo ^[1] ; Junqueira, Juliana Campos ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Mycopathologia; v. 185, n. 3, p. 415-424, JUN 2020.
• Citações Web of Science: 0

Resumo

Fungi of the genusCandidaare important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics ofCandidais its ability to form highly drug tolerance biofilms in the human host. Biofilms are a dynamic community of multiple cell types whose formation over time is orchestrated by a network of transcription regulators. In this brief review, we provide an update of the processes involved in biofilm formation byCandidaspp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms.Candida albicansis known to build mixed species biofilms with otherCandidaspecies and with various other bacterial species in different host niches. Taken together, these properties play a key role inCandidapathogenesis. In addition, this review gathers recent studies with new insights and perspectives for the treatment and control ofCandidabiofilms. (AU)

• Processo FAPESP: 19/05664-0 - Explorando o ácido cafeico (CA), éster fenetil do ácido cafeico (CAPE) e artepilina C (ARTC) como novas estratégias para eliminar as células persistentes de Candida albicans.
• Beneficiário: Patricia Pimentel de Barros
• Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 17/19219-3 - Identificação de substâncias bioativas produzidas por Lactobacillus paracasei 28.4 para o controle da candidose bucal
• Beneficiário: Rodnei Dennis Rossoni
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02652-6 - Avaliação dos efeitos imunomodulatórios e antifúngicos do ácido caféico (CA), do éster fenetil do ácido caféico (CAPE) e da artepillin C (ARC) sobre C. albicans e desenvolvimento de candidose em modelos hospedeiros in vivo
• Beneficiário: Patricia Pimentel de Barros
• Linha de fomento: Bolsas no Brasil - Pós-Doutorado