CandidaBiofilms: An Update on Developmental Mechanisms and Therapeutic Challenges

Author(s)

de Barros, Patricia Pimentel ^[1] ; Rossoni, Rodnei Dennis ^[1] ; de Souza, Cheyenne Marcal ^[1] ; Scorzoni, Liliana ^[1] ; Fenley, Juliana De Camargo ^[1] ; Junqueira, Juliana Campos ^[1]

Affiliation

^[1] Sao Paulo State Univ Unesp, Dept Biosci & Oral Diag, Inst Sci & Technol, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil

• Document type: Review article
• Source: Mycopathologia; v. 185, n. 3, p. 415-424, JUN 2020.
• Web of Science Citations: 0

Abstract

Fungi of the genusCandidaare important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics ofCandidais its ability to form highly drug tolerance biofilms in the human host. Biofilms are a dynamic community of multiple cell types whose formation over time is orchestrated by a network of transcription regulators. In this brief review, we provide an update of the processes involved in biofilm formation byCandidaspp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms.Candida albicansis known to build mixed species biofilms with otherCandidaspecies and with various other bacterial species in different host niches. Taken together, these properties play a key role inCandidapathogenesis. In addition, this review gathers recent studies with new insights and perspectives for the treatment and control ofCandidabiofilms. (AU)

• FAPESP's process: 19/05664-0 - Exploring the caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin c (ARTC) as new strategies to eliminate persisters cells of Candida albicans
• Grantee: Patrícia Pimentel de Barros
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis
• Grantee: Rodnei Dennis Rossoni
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/02652-6 - Evaluation of the immunomodulatory and antifungal effects of caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) on C. albicans and development of candidiasis in in vivo model hosts
• Grantee: Patrícia Pimentel de Barros
• Support Opportunities: Scholarships in Brazil - Post-Doctoral