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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Dexamethasone programs lower fatty acid absorption and reduced PPAR-gamma and fat/CD36 expression in the jejunum of the adult rat offspring

Texto completo
Autor(es):
de Souza, Dailson Nogueira [1] ; Teixeira, Caio Jordao [1] ; Veronesi, Vanessa Barbosa [1] ; Murata, Gilson Masahiro [2, 3] ; Santos-Silva, Junia Carolina [1] ; Hecht, Fernanda Ballerini [1] ; Vicente, Julia Modesto [1] ; Bordin, Silvana [2] ; Anhe, Gabriel Forato [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, 105 Alexander Flemming St, BR-13083881 Campinas, SP - Brazil
[2] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, 1524 Prof Linen Prestes Ave, ICB 1, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Dept Med Clin, BR-01246403 Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 265, JAN 15 2021.
Citações Web of Science: 0
Resumo

The progeny of rats born and breastfed by mothers receiving dexamethasone (DEX) during pregnancy exhibits permanent reduction in body weight and adiposity but the precise mechanisms related to this programming are not fully understood. In order to clarify this issue, the present study investigated key aspects of lipoprotein production and lipid metabolism by the liver and the intestine that would explain the reduced adiposity seen in the adult offspring exposed to DEX in utero. Female Wistar rats were treated with DEX (0.1 mg/kg/day) between the 15th and the 21st days of pregnancy, while control mothers were treated with vehicle. Male offspring born to control mothers were nursed by either adoptive control mothers (CTL/CTL) or DEX-treated mothers (CTL/DEX). Male offspring born to DEX-treated mothers were nursed by either control mothers (DEX/CTL) or adoptive DEX-treated mothers (DEX/DEX). We found that only the male DEX/DEX offspring had reduced adiposity. Additionally, male DEX/DEX progeny had lower circulating triacylglycerol (TAG) levels only in fed-state. The four groups of offspring presented similar energy expenditure, respiratory quotient and very low-density lipoprotein (VLDL) production. On the other hand, DEX/DEX rats displayed reduced TAG levels after gavage with olive oil and reduced expression of fatty acid translocase Cd36 (Fat/Cd36) and peroxisome proliferator-activated receptor gamma (Pparg) in the jejunum. Altogether, our study supports the notion that reduced fat absorption by the jejunum may contribute to the lower adiposity of the adult offspring born and breastfed by mothers treated with DEX during pregnancy. (AU)

Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 20/06397-3 - Investigação da senescência celular em roedores submetidos à Obesidade
Beneficiário:Caio Jordão Teixeira
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 19/03196-0 - Mecanismos moleculares envolvidos na inflexibilidade metabólica de ratos submetidos à programação fetal por excesso de glicocorticoides
Beneficiário:Silvana Auxiliadora Bordin da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 16/13138-9 - Efeito de agonistas de PPAR-gamma ou PPAR-alpha na programação metabólica decorrente de restrição calórica durante gestação e lactação
Beneficiário:Vanessa Barbosa Veronesi
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/23285-6 - Maturação e diferenciação do pâncreas endócrino em prole de fêmeas submetidas ao tratamento com dexametasona durante a prenhez
Beneficiário:Junia Carolina Rebelo dos Santos Silva
Linha de fomento: Bolsas no Brasil - Pós-Doutorado