Genome-wide translation patterns in gliomas: An integrative view

Autor(es)

Maroso Hajj, Glaucia Noeli ^{[1, 2]} ; Cordeiro Nunes, Paula Borzino ^[1] ; Roffe, Martin ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] AC Camargo Canc Ctr, Int Res Inst, Rua Tagua 440, BR-01508010 Sao Paulo - Brazil

^[2] Natl Inst Oncogen & Innovat, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CELLULAR SIGNALLING; v. 79, MAR 2021.
• Citações Web of Science: 0

Resumo

Gliomas are the most frequent tumors of the central nervous system (CNS) and include the highly malignant glioblastoma (GBM). Characteristically, gliomas have translational control deregulation related to overactivation of signaling pathways such as PI3K/AKT/mTORC1 and Ras/ERK1/2. Thus, mRNA translation appears to play a dominant role in glioma gene expression patterns. The, analysis of genome-wide translated transcripts, together known as the translatome, may reveal important information for understanding gene expression patterns in gliomas. This review provides a brief overview of translational control mechanisms altered in gliomas with a focus on the current knowledge related to the translatomes of glioma cells and murine glioma models. We present an integrative meta-analysis of selected glioma translatome data with the aim of identifying recurrent patterns of gene expression preferentially regulated at the level of translation and obtaining clues regarding the pathological significance of these alterations. Re-analysis of several translatome datasets was performed to compare the translatomes of glioma models with those of their non-tumor counterparts and to document glioma cell responses to radiotherapy and MNK modulation. The role of recurrently altered genes in the context of translational control and tumorigenesis are discussed. (AU)

• Processo FAPESP: 18/17796-6 - Controle traducional no câncer - Parte II
• Beneficiário: Glaucia Noeli Maroso Hajj
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/15451-3 - Estudo da Regulação e Função da família das RSKs em Glioblastomas
• Beneficiário: Martín Roffé
• Modalidade de apoio: Auxílio à Pesquisa - Regular