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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome-wide translation patterns in gliomas: An integrative view

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Author(s):
Maroso Hajj, Glaucia Noeli [1, 2] ; Cordeiro Nunes, Paula Borzino [1] ; Roffe, Martin [1, 2]
Total Authors: 3
Affiliation:
[1] AC Camargo Canc Ctr, Int Res Inst, Rua Tagua 440, BR-01508010 Sao Paulo - Brazil
[2] Natl Inst Oncogen & Innovat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: CELLULAR SIGNALLING; v. 79, MAR 2021.
Web of Science Citations: 0
Abstract

Gliomas are the most frequent tumors of the central nervous system (CNS) and include the highly malignant glioblastoma (GBM). Characteristically, gliomas have translational control deregulation related to overactivation of signaling pathways such as PI3K/AKT/mTORC1 and Ras/ERK1/2. Thus, mRNA translation appears to play a dominant role in glioma gene expression patterns. The, analysis of genome-wide translated transcripts, together known as the translatome, may reveal important information for understanding gene expression patterns in gliomas. This review provides a brief overview of translational control mechanisms altered in gliomas with a focus on the current knowledge related to the translatomes of glioma cells and murine glioma models. We present an integrative meta-analysis of selected glioma translatome data with the aim of identifying recurrent patterns of gene expression preferentially regulated at the level of translation and obtaining clues regarding the pathological significance of these alterations. Re-analysis of several translatome datasets was performed to compare the translatomes of glioma models with those of their non-tumor counterparts and to document glioma cell responses to radiotherapy and MNK modulation. The role of recurrently altered genes in the context of translational control and tumorigenesis are discussed. (AU)

FAPESP's process: 18/17796-6 - Translationa Control In Cancer - Part II
Grantee:Glaucia Noeli Maroso Hajj
Support Opportunities: Regular Research Grants
FAPESP's process: 15/15451-3 - Study on the Regulation and Function of the RSK Family in Glioblastomas
Grantee:Martín Roffé
Support Opportunities: Regular Research Grants