Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome

Autor(es):Mostrar menos -

Lopes, Alessandra G. D. ^[1] ; Celestino, Camila S. H. ^[1] ; Barros, Tiago T. A. ^{[2, 1]} ; Fevereiro, Aline G. ^[1] ; Gejer, Debora H. ^[1] ; Oliveira, Fernando M. F. ^[1] ; Brasil, Jamile M. ^[1] ; Bossolan, Rosely M. ^[1] ; Pinto, Gabriela C. C. ^[1] ; Santos, Ana C. E. Z. ^[1] ; Divan, Luis A. ^[1] ; Alves, Ingrid A. B. ^[1] ; Oliveira, Danielle B. L. ^{[3, 4]} ; Machado, Rafael R. G. ^[3] ; Thomazelli, Luciano M. ^[3] ; Hiyane, Meire I. ^[5] ; Brelaz-Abreu, Leonilia ^[2] ; Braganca-Jardim, Elayne ^[2] ; Heinen, Leticia B. S. ^[2] ; Barrientos, Anna C. M. ^[1] ; Mau, Luciana B. ^[1] ; Camara, Niels O. S. ^[5] ; Bueno, Daniela F. ^{[2, 1]} ; Amano, Mariane T. ^[2]

Afiliação do(s) autor(es)

^[1] Hosp Municipal Infantil Menino Jesus, Sao Paulo - Brazil

^[2] Hosp Sirio Libanes, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo - Brazil

^[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN MEDICINE; v. 8, MAR 12 2021.
• Citações Web of Science: 0

Resumo

Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection. (AU)

• Processo FAPESP: 17/24769-2 - Zika vírus em puérperas e neonatos: soroepidemiologia e caracterização molecular
• Beneficiário: Rafael Rahal Guaragna Machado
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 20/06409-1 - Avaliação da resposta imune humoral e da resposta inflamatória em pacientes com diagnóstico confirmado de COVID-19 no Hospital Sírio Libanês e correlação com a severidade da doença
• Beneficiário: Edison Luiz Durigon
• Modalidade de apoio: Auxílio à Pesquisa - Regular