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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome

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Lopes, Alessandra G. D. [1] ; Celestino, Camila S. H. [1] ; Barros, Tiago T. A. [2, 1] ; Fevereiro, Aline G. [1] ; Gejer, Debora H. [1] ; Oliveira, Fernando M. F. [1] ; Brasil, Jamile M. [1] ; Bossolan, Rosely M. [1] ; Pinto, Gabriela C. C. [1] ; Santos, Ana C. E. Z. [1] ; Divan, Luis A. [1] ; Alves, Ingrid A. B. [1] ; Oliveira, Danielle B. L. [3, 4] ; Machado, Rafael R. G. [3] ; Thomazelli, Luciano M. [3] ; Hiyane, Meire I. [5] ; Brelaz-Abreu, Leonilia [2] ; Braganca-Jardim, Elayne [2] ; Heinen, Leticia B. S. [2] ; Barrientos, Anna C. M. [1] ; Mau, Luciana B. [1] ; Camara, Niels O. S. [5] ; Bueno, Daniela F. [2, 1] ; Amano, Mariane T. [2]
Total Authors: 24
[1] Hosp Municipal Infantil Menino Jesus, Sao Paulo - Brazil
[2] Hosp Sirio Libanes, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo - Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: FRONTIERS IN MEDICINE; v. 8, MAR 12 2021.
Web of Science Citations: 0

Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection. (AU)

FAPESP's process: 17/24769-2 - Zika virus in postpartum women and newborns: seroepidemiology and molecular characterization
Grantee:Rafael Rahal Guaragna Machado
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 20/06409-1 - Evaluation of humoral immune response and inflammatory response in patients with confirmed diagnosis of COVID-19 at Hospital Sírio Libanês and correlation with disease severity
Grantee:Edison Luiz Durigon
Support type: Regular Research Grants