| Full text | |
| Author(s): Show less - |
Lopes, Alessandra G. D.
[1]
;
Celestino, Camila S. H.
[1]
;
Barros, Tiago T. A.
[2, 1]
;
Fevereiro, Aline G.
[1]
;
Gejer, Debora H.
[1]
;
Oliveira, Fernando M. F.
[1]
;
Brasil, Jamile M.
[1]
;
Bossolan, Rosely M.
[1]
;
Pinto, Gabriela C. C.
[1]
;
Santos, Ana C. E. Z.
[1]
;
Divan, Luis A.
[1]
;
Alves, Ingrid A. B.
[1]
;
Oliveira, Danielle B. L.
[3, 4]
;
Machado, Rafael R. G.
[3]
;
Thomazelli, Luciano M.
[3]
;
Hiyane, Meire I.
[5]
;
Brelaz-Abreu, Leonilia
[2]
;
Braganca-Jardim, Elayne
[2]
;
Heinen, Leticia B. S.
[2]
;
Barrientos, Anna C. M.
[1]
;
Mau, Luciana B.
[1]
;
Camara, Niels O. S.
[5]
;
Bueno, Daniela F.
[2, 1]
;
Amano, Mariane T.
[2]
Total Authors: 24
|
| Affiliation: | [1] Hosp Municipal Infantil Menino Jesus, Sao Paulo - Brazil
[2] Hosp Sirio Libanes, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo - Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | FRONTIERS IN MEDICINE; v. 8, MAR 12 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection. (AU) | |
| FAPESP's process: | 17/24769-2 - Zika virus in postpartum women and newborns: seroepidemiology and molecular characterization |
| Grantee: | Rafael Rahal Guaragna Machado |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 20/06409-1 - Evaluation of humoral immune response and inflammatory response in patients with confirmed diagnosis of COVID-19 at Hospital Sírio Libanês and correlation with disease severity |
| Grantee: | Edison Luiz Durigon |
| Support Opportunities: | Regular Research Grants |