Viral infection and smell loss: The case of COVID-19

Autor(es)

Glezer, Isaias ^[1] ; Bruni-Cardoso, Alexandre ^[2] ; Schechtman, Deborah ^[2] ; Malnic, Bettina ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, UNIFESP, Rua Tres Maio, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Biochem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Journal of Neurochemistry; v. 157, n. 4, p. 930-943, MAY 2021.
• Citações Web of Science: 7

Resumo

Olfactory disorders have been increasingly reported in individuals infected with SARS-CoV-2, the virus causing the coronavirus disease 2019 (COVID-19). Losing the sense of smell has a strong impact on the quality of life, since it may lead to malnutrition, weight loss, food poisoning, depression, and exposure to dangerous chemicals. Individuals who suffer from anosmia (inability to smell) also cannot sense the flavor of food, which is a combination of taste and smell. Interestingly, infected individuals have reported sudden loss of smell with no congested nose, as is frequently observed in common colds or other upper respiratory tract infections. These observations suggest that SARS-CoV-2 infection leads to olfactory loss through a distinct mechanism, which is still unclear. This article provides an overview of olfactory loss and the recent findings relating to COVID-19. Possible mechanisms of SARS-CoV-2-induced olfactory loss are also discussed. (AU)

• Processo FAPESP: 19/26767-2 - Regulação da proteostase de MST2 na via Hippo
• Beneficiário: Alexandre Bruni Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/06982-6 - Caracterização e desenvolvimento de novos moduladores das vias da TrkA e PKMzeta na dor inflamatória e crônica
• Beneficiário: Deborah Schechtman
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/18633-3 - Sinalização e Modificação Lipídica via Receptor CD36 no Sistema Nervoso
• Beneficiário: Isaias Glezer
• Modalidade de apoio: Auxílio à Pesquisa - Regular