| Full text | |
| Author(s): |
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Paulo, Dept Biochem, Escola Paulista Med, UNIFESP, Rua Tres Maio, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Biochem, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | Journal of Neurochemistry; v. 157, n. 4, p. 930-943, MAY 2021. |
| Web of Science Citations: | 7 |
| Abstract | |
Olfactory disorders have been increasingly reported in individuals infected with SARS-CoV-2, the virus causing the coronavirus disease 2019 (COVID-19). Losing the sense of smell has a strong impact on the quality of life, since it may lead to malnutrition, weight loss, food poisoning, depression, and exposure to dangerous chemicals. Individuals who suffer from anosmia (inability to smell) also cannot sense the flavor of food, which is a combination of taste and smell. Interestingly, infected individuals have reported sudden loss of smell with no congested nose, as is frequently observed in common colds or other upper respiratory tract infections. These observations suggest that SARS-CoV-2 infection leads to olfactory loss through a distinct mechanism, which is still unclear. This article provides an overview of olfactory loss and the recent findings relating to COVID-19. Possible mechanisms of SARS-CoV-2-induced olfactory loss are also discussed. (AU) | |
| FAPESP's process: | 19/26767-2 - Proteostasis regulation of MST2 in the Hippo pathway |
| Grantee: | Alexandre Bruni Cardoso |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/06982-6 - Characterization and development of new modulators of the TrkA and PKMzeta pathways in inflammatory and chronic pain |
| Grantee: | Deborah Schechtman |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine |
| Grantee: | Ohara Augusto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 18/18633-3 - Lipid Modification and Signaling through CD36 Receptor in the Nervous System |
| Grantee: | Isaias Glezer |
| Support Opportunities: | Regular Research Grants |