Carotid intima-media thickness and metabolic syndrome in a rural population: Results from the Baependi Heart Study

Autor(es)

Geovanini, Glaucylara Reis ^{[1, 2]} ; de Sousa, Iguaracy Pinheiro ^[1] ; Teixeira, Samantha Kuwada ^[1] ; Francisco Neto, Miguel Jose ^{[3, 4]} ; Gomez Gomez, Luz Marina ^[1] ; Del Guerra, Guilherme Ciconelli ^[3] ; Pereira, Alexandre Costa ^[1] ; Krieger, Jose Eduardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Genet & Mol Cardiol Lab, InCor Heart Inst, Av Dr Eneas Carvalho Aguiar 44, Bloco 2, 10th Floor, BR-05403000 Sao Paulo, SP - Brazil

^[2] Hosp Coracao HCor, HCor Res Inst, Sao Paulo, SP - Brazil

^[3] Hosp Israelita Albert Einstein HIAE, Dept Imaging, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Med Sch, Inst Radiol InRad, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL CARDIOLOGY HYPERTENSION; v. 6, SEP 2020.
• Citações Web of Science: 1

Resumo

Background and aims: Carotid intima-media thickness (cIMT) is a strong predictor of cardiovascular events and associated with metabolic syndrome (MetS). MetS is a cluster of cardiovascular risk factors, but the association structure between specific factors and disease development is not well-established in rural populations. We described the association structure between MetS factors and cIMT in a sample from rural Brazil. Methods: We studied 1937 participants from the Baependi Heart Study who underwent carotid ultrasound exam. We used ATP-III-2001 for MetS definition and linear mixed-effects models, adjusting by the family structure, to assess independent associations between the cardiovascular risk factors which define MetS and cIMT. Results: The sample's mean age was 46 +/- 16y, 61% female, 73% white, mean body-mass-index 26 +/- 5 kg/m(2), mean cIMT 0.53 +/- 0.16 mm, with 35% of the sample classified with MetS. As expected, cIMT demonstrated a linear relationship with increasing age, and cIMT higher values were observed for MetS (0.58 +/- 0.16 mm) compared to non-MetS (0.49 +/- 0.14 mm). Considering models for cIMT with MetS and all of its factors, we found that blood pressure, glucose and obesity were independently associated with cIMT, but not HDL or triglycerides. Conclusions: cIMT showed a linear relationship with increasing age. Blood pressure, obesity, and glucose were independently associated with cIMT, but not HDL-cholesterol or triglycerides. In a rural population, hypertension, diabetes and obesity play a more important role than lipids in determining cIMT interindividual variability. (AU)

• Processo FAPESP: 11/05804-5 - Caracterização fenotípica de ritmos circadianos em indivíduos com diferentes genótipos para polimorfismos nos genes relógio em diferentes regiões do Brasil: ênfase na investigação do gene PER3 e o efeito latitude
• Beneficiário: Mario Pedrazzoli Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/58150-7 - Mapeamento genético de fatores de risco cardiovascular na população brasileira: uma abordagem de mapeamento baseada em núcleos familiares: Projeto Corações de Baependi
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/51010-8 - Estudos de associacao genomica ampla de fatores de risco associados a doencas cardiovasculares em uma amostra populacional brasileira.
• Beneficiário: Andréa Roseli Vançan Russo Horimoto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado