| Texto completo | |
| Autor(es): |
Marchi-Coelho, Camila
[1]
;
Costa-Ferreira, Willian
[1, 2]
;
Reis-Silva, Lilian L.
[1, 2]
;
Crestani, Carlos C.
[1, 2]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
[2] Joint UFSCar UNESP Grad Program Physiol Sci, BR-13565905 Sao Carlos, SP - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELLS; v. 10, n. 5 MAY 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
We investigated the role of angiotensin II type 1 (AT(1) receptor) and type 2 (AT(2) receptor) and MAS receptors present in the medial amygdaloid nucleus (MeA) in behavioral changes in the forced swimming test (FST) evoked by acute restraint stress in male rats. For this, rats received bilateral microinjection of either the selective AT(1) receptor antagonist losartan, the selective AT(2) receptor antagonist PD123319, the selective MAS receptor antagonist A-779, or vehicle 10 min before a 60 min restraint session. Then, behavior in the FST was evaluated immediately after the restraint (15 min session) and 24 h later (5 min session). The behavior in the FST of a non-stressed group was also evaluated. We observed that acute restraint stress decreased immobility during both sessions of the FST in animals treated with vehicle in the MeA. The decreased immobility during the first session was inhibited by intra-MeA administration of PD123319, whereas the effect during the second session was not identified in animals treated with A-779 into the MeA. Microinjection of PD123319 into the MeA also affected the pattern of active behaviors (i.e., swimming and climbing) during the second session of the FST. Taken together, these results indicate an involvement of angiotensinergic neurotransmissions within the MeA in behavioral changes in the FST evoked by stress. (AU) | |
| Processo FAPESP: | 18/23686-9 - Envolvimento de neurotransmissões angiotensinérgicas no núcleo medial da amígdala nas alterações comportamentais no teste de nado forçado induzidas pelo estresse de restrição em ratos |
| Beneficiário: | Camila Marchi Coelho |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 19/24478-3 - Estudo da participação do córtex insular no controle das respostas cardiovasculares e ansiogênica ao estresse em ratos: avaliação da topografia funcional e do envolvimento da neurotransmissão do fator de liberação de corticotrofina (CRF) |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/05218-2 - Envolvimento das sinalizações angiotensina II/receptor AT1 e angiotensina 1-7/ receptor Mas no núcleo medial da amígdala nas respostas cardiovasculares e ansiogênica ao estresse em ratos |
| Beneficiário: | Willian Costa Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |