The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Autor(es):Mostrar menos -

Stein, Erika M. ^[1] ; Taju, Sara G. ^[2] ; Miyasato, Patricia A. ^[2] ; de Freitas, Rafaela P. ^[2] ; Tallarico, Lenita de F. ^[2] ; dos Santos, Guilherme S. ^[2] ; Luiz, Giovana L. F. ^[2] ; Rofatto, Henrique K. ^[2] ; da Silva, Fabio N. V. ^[2] ; Colepicolo, Pio ^[1] ; Macedo, Arthur L. ^[3] ; Carollo, Carlos A. ^[3] ; Nakano, Eliana ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Chem, Lab Biochem & Mol Biol Marine Algae, BR-05508090 Sao Paulo, SP - Brazil

^[2] Butantan Inst, Parasitol Lab, BR-05503900 Sao Paulo, SP - Brazil

^[3] Univ Fed Mato Grosso do Sul, Lab Nat Prod & Mass Spectrometry LaPNEM, Fac Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MARINE DRUGS; v. 19, n. 5 MAY 2021.
• Citações Web of Science: 0

Resumo

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC-MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification. (AU)

• Processo FAPESP: 16/06931-4 - Biodiversidade e prospecção de algas de águas tropicais e da Antártica marítima
• Beneficiário: Pio Colepicolo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 17/07346-0 - Estudo de análogos baseados em produtos naturais de algas marinhas do gênero Laurencia (Rhodophyta, Ceramiales) para o controle de doenças tropicais negligenciadas
• Beneficiário: Erika Mattos Stein
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/16223-7 - Planejamento e síntese de compostos bioativos originados de algas marinhas para combater a esquistossomose
• Beneficiário: Eliana Nakano
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular