The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control

Author(s):Show less -

Stein, Erika M. ^[1] ; Taju, Sara G. ^[2] ; Miyasato, Patricia A. ^[2] ; de Freitas, Rafaela P. ^[2] ; Tallarico, Lenita de F. ^[2] ; dos Santos, Guilherme S. ^[2] ; Luiz, Giovana L. F. ^[2] ; Rofatto, Henrique K. ^[2] ; da Silva, Fabio N. V. ^[2] ; Colepicolo, Pio ^[1] ; Macedo, Arthur L. ^[3] ; Carollo, Carlos A. ^[3] ; Nakano, Eliana ^[2]

Affiliation

^[1] Univ Sao Paulo, Inst Chem, Lab Biochem & Mol Biol Marine Algae, BR-05508090 Sao Paulo, SP - Brazil

^[2] Butantan Inst, Parasitol Lab, BR-05503900 Sao Paulo, SP - Brazil

^[3] Univ Fed Mato Grosso do Sul, Lab Nat Prod & Mass Spectrometry LaPNEM, Fac Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS - Brazil

• Document type: Journal article
• Source: MARINE DRUGS; v. 19, n. 5 MAY 2021.
• Web of Science Citations: 0

Abstract

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against Biomphalaria glabrata embryos and schistosomicidal activities against Schistosoma mansoni. Two sets of extracts were taxonomically grouped for metabolomic analysis. The extracts were analyzed by GC-MS, and the data were subjected to Pattern Hunter and Pearson correlation tests. Overall, 22 species (60%) showed activity in at least one of the two models. Multivariate analysis pointed towards 3 hits against B. glabrata veliger embryos in the Laurencia/Laurenciella set, 5 hits against B. glabrata blastula embryos, and 31 against S. mansoni in the Ochrophyta set. Preliminary annotations suggested some compounds such as triquinane alcohols, prenylated guaianes, dichotomanes, and xenianes. Despite the putative identification, this work presents potential candidates and can guide future isolation and identification. (AU)

• FAPESP's process: 16/06931-4 - Biodiversity of marine algae and metabolites of economical impact
• Grantee: Pio Colepicolo Neto
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 17/07346-0 - Study of analogues based on marine natural products from species ofgenus Laurencia (Rhodophyta, Ceramiales) for the control of neglected tropical diseases
• Grantee: Erika Mattos Stein
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/16223-7 - Designing and synthesis of bioactive compounds from marine algae against schistosomiasis
• Grantee: Eliana Nakano
• Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants