Cytotoxic profile of CD3+CD20+T cells in progressive multiple sclerosis

Autor(es)

Boldrini, Vinicius O. ^{[1, 2, 3]} ; Quintiliano, Raphael P. S. ^[3] ; Silva, Lucas S. ^[4] ; Damasceno, Alfredo ^[4] ; Santos, Leonilda M. B. ^{[1, 2, 3]} ; Farias, Alessandro S. ^{[1, 2, 3, 5]}

Afiliação do(s) autor(es)

^[1] Natl Inst Sci & Technol Neuroimmunomodulat INCT N, Rio De Janeiro - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Genet Microbiol & Immunol, Autoimmune Res Lab, Campinas - Brazil

^[3] Univ Estadual Campinas, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Neuroimmunol Unit, Campinas - Brazil

^[4] Univ Estadual Campinas, Dept Neurol, Campinas - Brazil

^[5] Expt Med Res Cluster, Div Immune Mediated Dis, Campinas - Brazil

• Tipo de documento: Carta
• Fonte: MULTIPLE SCLEROSIS AND RELATED DISORDERS; v. 52, JUL 2021.
• Citações Web of Science: 0

Resumo

Recently, it was shown that highly effective anti-CD20 therapies used for MS patients not only deplete CD20+ B cells, but also a small subset of T cells expressing CD20 surface marker (CD3+CD20+ T cells). Here we demonstrated that, in progressive MS patients, CD3+CD20+ T cells share the ability to express cytotoxic factors such as perforin and serine-protease granzyme-B (GzmB), classically associated with CD8+ T cells functionality. Beyond it, cluster analyses show that a set of activation markers and transcriptional factors related with CD8 effector program are also expressed in CD3+CD20+ T cells. Further characterization of surface and functional markers from CD3+CD20+ T subsets may be helpful for development of new therapeutic strategies mainly for progressive MS patients, as well as for assessing pathophysiological effects of highly effective anti-CD20 therapies. (AU)

• Processo FAPESP: 17/21363-5 - Regulação da via JAK/STAT/SOCS na mudança de perfil de Th17 para Th1 (produtoras de IFNg) durante a evolução clínica da encefalomielite experimental autoimune
• Beneficiário: Alessandro dos Santos Farias
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/06372-3 - Aquisição de citômetro de fluxo multiparamétrico
• Beneficiário: Alessandro dos Santos Farias
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 14/26431-0 - Esclerose múltipla, estudo clínico, neuropsicológico, imunológico, biomarcadores e novas drogas modificadoras da doença
• Beneficiário: Leonilda Maria Barbosa dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Temático