Pre- and Post-Conditioning of the Heart: An Overview of Cardioprotective Signaling Pathways

Autor(es)

Miranda, Denise Coutinho de ^{[1, 2]} ; Faria, Gabriela de Oliveira ^{[1, 2]} ; Hermidorff, Milla Marques ^{[1, 2]} ; Silva, Fernanda Cacilda dos Santos ^{[2, 3]} ; Assis, Leonardo Vinicius Monteiro de ^[4] ; Isoldi, Mauro Cesar ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Res Ctr Biol Sci, Cell Signaling Lab, Campus Morro Cruzeiro, BR-35400000 Ouro Preto, MG - Brazil

^[2] Univ Fed Ouro Preto, Grad Program Biol Sci CBIOL NUPEB, Ouro Preto - Brazil

^[3] Univ Fed Ouro Preto, Inst Exact & Biol Sci, Dept Biol Sci, Lab Cardiovasc Physiol, Ouro Preto - Brazil

^[4] Uni Sao Paulo, Inst Biosci, Dept Physiol, Lab Comparat Physiol Pigmentat, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT VASCULAR PHARMACOLOGY; v. 19, n. 5, p. 499-524, 2021.
• Citações Web of Science: 0

Resumo

Since the discovery of ischemic pre- and post-conditioning, more than 30 years ago, the knowledge about the mechanisms and signaling pathways involved in these processes has significantly increased. In clinical practice, on the other hand, such advancement has yet to be seen. This article provides an overview of ischemic pre-, post-, remote, and pharmacological conditioning related to the heart. In addition, we reviewed the cardioprotective signaling pathways and therapeutic agents involved in the above-mentioned processes, aiming to provide a comprehensive evaluation of the advancements in the field. The advancements made over the last decades cannot be ignored and with the exponential growth in techniques and applications. The future of pre- and post-conditioning is promising. (AU)

• Processo FAPESP: 18/16511-8 - Participação dos sistemas de fotorrecepção e de controle temporal no desenvolvimento, progressão e metástase do melanoma maligno: investigação de novos alvos terapêuticos
• Beneficiário: Leonardo Vinícius Monteiro de Assis
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado