| Texto completo | |
| Autor(es): |
Parolin, Giovana A.
[1]
;
Passero, Luiz Felipe D.
[2, 3]
;
Lago, Joao Henrique G.
[4]
;
Peres, Laura Oliveira
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Fed Univ Sao Paulo UNIFESP, Chem Dept, Lab Hybrid Mat, Diadema, SP - Brazil
[2] Sao Paulo State Univ Unesp, Inst Biosci, Sao Vicente, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Adv Studies Ocean, Sao Vicente, SP - Brazil
[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Lab Chem Biol, Santo Andre, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INDUSTRIAL CROPS AND PRODUCTS; v. 171, NOV 1 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
A new biobased compound was prepared from commercially available monoterpene thymol, obtained from the essential oil of a cultivated plant, Thymus vulgaris L. (Lamiaceae), together with formaldehyde. The final product, poly(thymolformaldehyde), namely PTF, was characterized by infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), UV-vis spectroscopy, fluorescence, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), and differential scattering calorimetry (DSC). NMR associated with FTIR data analysis evidenced the occurrence of polymerization at C-1 and C-5 positions of thymol. UV-vis and fluorescence analysis showed that the prepared material exhibited absorption and emission bands at 285 and 313 nm, respectively. GPC data analysis displayed a polydisperse material (PDI = 1.99) with a molar mass of approximately 1375 Da, while TGA analysis showed a high thermal resistance (ranging from 150 to 800 degrees C). PTF was evaluated against promastigote forms of Leishmania (Leishmania) amazonensis and exhibited effective concentration 50 % (EC50) of 8.4 +/- 0.8 mu g/mL as well as reduced toxicity to macrophages (cytotoxic concentration 50 % - CC50 > 100 mu g/mL and SI > 11.9). Therefore, the effects of PTF against L. (L.) amazonensis, together with its simple preparation using commercially available reagents (thymol and formaldehyde), suggest that this polymer could be a promising candidate for new biobased drugs to treat cutaneous leishmaniasis. (AU) | |
| Processo FAPESP: | 18/07885-1 - Biomoléculas oriundas de espécies vegetais de áreas remanescentes da Mata Atlântica e do Cerrado para tratamento de doenças tropicais negligenciadas - aspectos químicos e farmacológicos |
| Beneficiário: | João Henrique Ghilardi Lago |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Regular |
| Processo FAPESP: | 18/24077-6 - Estudos pré-clínicos de tratamentos não invasivos nas leishmanioses |
| Beneficiário: | Luiz Felipe Domingues Passero |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/18180-9 - 2018 MRS Fall Meetings & Exhibits |
| Beneficiário: | Laura Oliveira Péres Philadelphi |
| Modalidade de apoio: | Auxílio à Pesquisa - Reunião - Exterior |
| Processo FAPESP: | 14/50869-6 - INCT 2014: em Eletrônica Orgânica INEO |
| Beneficiário: | Roberto Mendonça Faria |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |