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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antileishmanial activity evaluation of poly(thymolformaldehyde)-A biobased material from thymol

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Author(s):
Parolin, Giovana A. [1] ; Passero, Luiz Felipe D. [2, 3] ; Lago, Joao Henrique G. [4] ; Peres, Laura Oliveira [1]
Total Authors: 4
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Chem Dept, Lab Hybrid Mat, Diadema, SP - Brazil
[2] Sao Paulo State Univ Unesp, Inst Biosci, Sao Vicente, SP - Brazil
[3] Sao Paulo State Univ UNESP, Inst Adv Studies Ocean, Sao Vicente, SP - Brazil
[4] Fed Univ ABC UFABC, Ctr Nat & Human Sci, Lab Chem Biol, Santo Andre, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INDUSTRIAL CROPS AND PRODUCTS; v. 171, NOV 1 2021.
Web of Science Citations: 0
Abstract

A new biobased compound was prepared from commercially available monoterpene thymol, obtained from the essential oil of a cultivated plant, Thymus vulgaris L. (Lamiaceae), together with formaldehyde. The final product, poly(thymolformaldehyde), namely PTF, was characterized by infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), UV-vis spectroscopy, fluorescence, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), and differential scattering calorimetry (DSC). NMR associated with FTIR data analysis evidenced the occurrence of polymerization at C-1 and C-5 positions of thymol. UV-vis and fluorescence analysis showed that the prepared material exhibited absorption and emission bands at 285 and 313 nm, respectively. GPC data analysis displayed a polydisperse material (PDI = 1.99) with a molar mass of approximately 1375 Da, while TGA analysis showed a high thermal resistance (ranging from 150 to 800 degrees C). PTF was evaluated against promastigote forms of Leishmania (Leishmania) amazonensis and exhibited effective concentration 50 % (EC50) of 8.4 +/- 0.8 mu g/mL as well as reduced toxicity to macrophages (cytotoxic concentration 50 % - CC50 > 100 mu g/mL and SI > 11.9). Therefore, the effects of PTF against L. (L.) amazonensis, together with its simple preparation using commercially available reagents (thymol and formaldehyde), suggest that this polymer could be a promising candidate for new biobased drugs to treat cutaneous leishmaniasis. (AU)

FAPESP's process: 18/07885-1 - Biomolecules from plant species of remnant areas of the Atlantic Forest and Cerrado to treat neglected tropical diseases - chemical and pharmacological aspects
Grantee:João Henrique Ghilardi Lago
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 18/24077-6 - Pre-clinical studies of non-invasive treatments in leishmaniasis
Grantee:Luiz Felipe Domingues Passero
Support Opportunities: Regular Research Grants
FAPESP's process: 18/18180-9 - 2018 MRS Fall Meetings & Exhibits
Grantee:Laura Oliveira Péres Philadelphi
Support Opportunities: Research Grants - Meeting - Abroad
FAPESP's process: 14/50869-6 - INCT 2014: on Organic Electronics
Grantee:Roberto Mendonça Faria
Support Opportunities: Research Projects - Thematic Grants