Heart rate fragmentation, a novel approach in heart rate variability analysis, is altered in rats 4 and 12 weeks after myocardial infarction

Autor(es)

Omoto, Ana Carolina M. ^[1] ; Lataro, Renata M. ^[2] ; Silva, Thais M. ^[1] ; Salgado, Helio Cesar ^[1] ; Fazan Jr, Rubens ; Virgilio Silva, Luiz Eduardo ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, Florianopolis, SC - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING; v. 59, n. 11-12 OCT 2021.
• Citações Web of Science: 0

Resumo

An approach recently proposed to assess ultra-rapid patterns of heart rate variability, namely heart rate fragmentation (HRF), is increased in aging and coronary disease. We aimed to evaluate and to correlate HRF with cardiac functional parameters in a rat model of myocardial infarction (MI). Wistar rats were submitted to MI (n = 18) or sham operation (n = 20), and after 4 or 12 weeks, their arterial pressure was recorded. Subsequently, cardiac function was evaluated by echocardiography. From pulse interval series, HRF patterns with zero, one, two, or three inflection points were estimated, as well as the total percentage of inflection points (PIP). Cardiac function was reduced in MI rats. Ejection fraction was smaller 4 (28 +/- 3 vs 68 +/- 2%, p < 0.0001) and 12 weeks after MI (38 +/- 3 vs 70 +/- 3%, p < 0.0001). Fractional shortening was also smaller 4 (13 +/- 2 vs 41 +/- 2%, p < 0.0001) and 12 weeks after MI (20 +/- 2 vs 41 +/- 3%, p < 0.0001). PIP was increased in MI rats 4 (74 +/- 2 vs 69 +/- 1%, p = 0.03) and 12 weeks after surgery (70 +/- 2 vs 63 +/- 1%, p = 0.02). We found a significant negative correlation between cardiac functional parameters and HRF at both 4 and 12 weeks after MI. These findings reveal that MI increases HRF, reinforcing the importance of this approach to explore pathophysiological conditions. (AU)

• Processo FAPESP: 13/20549-7 - Avanços na regulação cardiocirculatória em condições fisiológica e fisiopatológica
• Beneficiário: Helio Cesar Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Temático