anana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammatio

Autor(es)

Barroso, Wermerson Assuncao ^[1] ; Serra, Mariana Barreto ^[1] ; Abreu, Iracelle Carvalho ^[2] ; Barbeiro, Hermes Vieira ^[1] ; Fiamoncini, Jarlei ^[3] ; Rinaldi de Alvarenga, Jose Fernando ^[3] ; de Souza, Heraldo Possolo ^[1] ; de Lima, Thais Martins ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Med Sch, Emergency Med Dept, Sao Paulo, SP - Brazil

^[2] Univ Fed Maranhao, Physiol Sci Dept, Lab Res & Postgrad Pharmacol LPPF, Sao Luis, Maranhao - Brazil

^[3] Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 36, n. 2 JAN 2022.
• Citações Web of Science: 0

Resumo

We investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity. (AU)

• Processo FAPESP: 17/12843-3 - Modulação dos parâmetros metabólicos e inflamatórios pelo extrato hidroalcoólico das cascas de Musa cavendishii na obesidade induzida por dieta hiperlipídica
• Beneficiário: Thais Martins de Lima Salgado
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/07914-8 - FoRC - Centro de Pesquisa em Alimentos
• Beneficiário: Bernadette Dora Gombossy de Melo Franco
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 19/11324-8 - Avaliação dos efeitos do D-limoneno no metabolismo intermediário de camundongos: relação entre o metabolismo do D-limoneno e os efeitos na saúde
• Beneficiário: José Fernando Rinaldi de Alvarenga
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado