Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

anana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammatio

Full text
Author(s):
Barroso, Wermerson Assuncao [1] ; Serra, Mariana Barreto [1] ; Abreu, Iracelle Carvalho [2] ; Barbeiro, Hermes Vieira [1] ; Fiamoncini, Jarlei [3] ; Rinaldi de Alvarenga, Jose Fernando [3] ; de Souza, Heraldo Possolo [1] ; de Lima, Thais Martins [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Med Sch, Emergency Med Dept, Sao Paulo, SP - Brazil
[2] Univ Fed Maranhao, Physiol Sci Dept, Lab Res & Postgrad Pharmacol LPPF, Sao Luis, Maranhao - Brazil
[3] Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Phytotherapy Research; v. 36, n. 2 JAN 2022.
Web of Science Citations: 0
Abstract

We investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity. (AU)

FAPESP's process: 17/12843-3 - Modulation of metabolic and inflammatory parameters by the hydroalcoholic extract of Musa cavendishii in high fat diet obesity
Grantee:Thais Martins de Lima Salgado
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/11324-8 - Evaluation of D-limonene effects on intermediate metabolism of mice: relationship between limonene metabolism and health effects
Grantee:José Fernando Rinaldi de Alvarenga
Support Opportunities: Scholarships in Brazil - Post-Doctoral