anana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammatio

Author(s)

Barroso, Wermerson Assuncao ^[1] ; Serra, Mariana Barreto ^[1] ; Abreu, Iracelle Carvalho ^[2] ; Barbeiro, Hermes Vieira ^[1] ; Fiamoncini, Jarlei ^[3] ; Rinaldi de Alvarenga, Jose Fernando ^[3] ; de Souza, Heraldo Possolo ^[1] ; de Lima, Thais Martins ^[1]

Affiliation

^[1] Univ Sao Paulo, Med Sch, Emergency Med Dept, Sao Paulo, SP - Brazil

^[2] Univ Fed Maranhao, Physiol Sci Dept, Lab Res & Postgrad Pharmacol LPPF, Sao Luis, Maranhao - Brazil

^[3] Univ Sao Paulo, Food Res Ctr FoRC, Sch Pharmaceut Sci, Dept Food Sci & Expt Nutr, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Phytotherapy Research; v. 36, n. 2 JAN 2022.
• Web of Science Citations: 0

Abstract

We investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity. (AU)

• FAPESP's process: 17/12843-3 - Modulation of metabolic and inflammatory parameters by the hydroalcoholic extract of Musa cavendishii in high fat diet obesity
• Grantee: Thais Martins de Lima Salgado
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07914-8 - FoRC - Food Research Center
• Grantee: Bernadette Dora Gombossy de Melo Franco
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 19/11324-8 - Evaluation of D-limonene effects on intermediate metabolism of mice: relationship between limonene metabolism and health effects
• Grantee: José Fernando Rinaldi de Alvarenga
• Support Opportunities: Scholarships in Brazil - Post-Doctoral