| Texto completo | |
| Autor(es): Mostrar menos - |
Papaiz, Debora D'Angelo
;
Rius, Flavia Eichemberger
;
Ayub, Ana Luisa Pedroso
;
Origassa, Clarice S.
;
Gujar, Hemant
;
Pessoa, Diogo de Oliveira
;
Reis, Eduardo Moraes
;
Nsengimana, Jeremie
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Newton-Bishop, Julia
;
Mason, Christopher E.
;
Weisenberger, Daniel J.
;
Liang, Gangning
;
Jasiulionis, Miriam Galvonas
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | MOLECULAR ONCOLOGY; v. 16, n. 9, p. 18-pg., 2022-02-04. |
| Resumo | |
In addition to mutations, epigenetic alterations are important contributors to malignant transformation and tumor progression. The aim of this work was to identify epigenetic events in which promoter or gene body DNA methylation induces gene expression changes that drive melanocyte malignant transformation and metastasis. We previously developed a linear mouse model of melanoma progression consisting of spontaneously immortalized melanocytes, premalignant melanocytes, a nonmetastatic tumorigenic, and a metastatic cell line. Here, through the integrative analysis of methylome and transcriptome data, we identified the relationship between promoter and/or gene body DNA methylation alterations and gene expression in early, intermediate, and late stages of melanoma progression. We identified adenylate cyclase type 3 (Adcy3) and inositol polyphosphate 4-phosphatase type II (Inpp4b), which affect tumor growth and metastatic potential, respectively. Importantly, the gene expression and DNA methylation profiles found in this murine model of melanoma progression were correlated with available clinical data from large population-based primary melanoma cohorts, revealing potential prognostic markers. (AU) | |
| Processo FAPESP: | 19/23480-4 - Novas estratégias para eliminação de células tumorais residuais utilizando terapia epigenética |
| Beneficiário: | Miriam Galvonas Jasiulionis |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/13663-0 - Integração de dados de expressão de genes e microRNAs, metiloma e hidroximetiloma de diferentes etapas da progressão do melanoma. |
| Beneficiário: | Miriam Galvonas Jasiulionis |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/20775-0 - RNAs não codificantes envolvidos com a gênese e a progressão do melanoma |
| Beneficiário: | Miriam Galvonas Jasiulionis |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |