Omega-3 pleiad: The multipoint anti-inflammatory strategy

Autor(es)

Batista, Ellencristina da Silva ; Branco Ramos Nakandakari, Susana Castelo ; Ramos da Silva, Adelino Sanchez ; Pauli, Jose Rodrigo ; de Moura, Leandro Pereira ; Ropelle, Eduardo Rochete ; Camargo, Enilton A. ; Cintra, Dennys Esper

• Tipo de documento: Artigo Científico
• Fonte: CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. N/A, p. 16-pg., 2022-11-10.

Resumo

Omega 3 (omega 3) fatty acids have been described since the 1980s as promising anti-inflammatory substances. Prostaglandin and leukotriene modulation were exhaustively explored as the main reason for omega 3 beneficial outcomes. However, during the early 2000s, after the human genome decoding advent, the nutrigenomic approaches exhibited an impressive plethora of omega 3 targets, now under the molecular point of view. Different G protein-coupled receptors (GPCRs) recognizing omega 3 and its derivatives appear to be responsible for blocking inflammation and insulin-sensitizing effects. A new class of omega 3-derived substances, such as maresins, resolvins, and protectins, increases omega 3 actions. Inflammasome disruption, the presence of GPR120 on immune cell surfaces, and intracellular crosstalk signaling mediated by PPAR gamma compose the last discoveries regarding the multipoint anti-inflammatory targets for this nutrient. This review shows a detailed mechanistic proposal to understand omega 3 fatty acid action over the inflammatory environment in the background of several chronic diseases. (AU)

• Processo FAPESP: 20/13443-1 - Implicações do exercício físico aeróbio sobre a via de sinalização da Notch 1 e regulação da lipogênese e gliconeogênese no fígado
• Beneficiário: José Rodrigo Pauli
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/13210-0 - Avaliação do mecanismo molecular de ação dos ácidos graxos ômega-3 no desenvolvimento precoce da Doença de Alzheimer associada à obesidade e Diabetes tipo 2 em camundongos: papel do receptor GPR120
• Beneficiário: Dennys Esper Corrêa Cintra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/13168-3 - A influência do GPR120 no sistema imune
• Beneficiário: Susana Castelo Branco Ramos Nakandakari
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto