Silk Fibroin Hydrogels Incorporated with the Antioxidant Extract of Stryphnodendron adstringens Bark

Autor(es)

de Brito, Vivian P. ; de Souza Ribeiro, Mauricio M. ; Vigano, Juliane ; de Moraes, Mariana A. ; Veggi, Priscilla C.

• Tipo de documento: Artigo Científico
• Fonte: POLYMERS; v. 14, n. 22, p. 15-pg., 2022-11-01.

Resumo

Barbatimao (Stryphnodendron adstringens) is a Brazilian medicinal plant known for its pharmacological properties, including healing activity related to its phenolic composition, which is chiefly given by tannins. In order to preserve its stability and bioactivity, barbatimao extracts can be incorporated into (bio-)polymeric matrixes, of which silk fibroin stands out due to its versatility and tunable properties. This work aimed to obtain barbatimao bark extract rich in phenolic compounds and evaluate its incorporation in fibroin hydrogels. From the extraction process, it was observed that the PG (propylene glycol) extract presented a higher global yield (X-0) and phenolic compounds (TPC) than the ET (ethanol) extract. Furthermore, the antioxidant activity (ORAC and FRAP) was similar between both extracts. Regarding the hydrogels, morphological, chemical, thermal, and mechanical characterizations were performed to understand the influence of the barbatimao extract and the solvent on the fibroin hydrogel properties. As a result, the hydrogels containing the barbatimao PG extract (BT/PG hydrogels) showed the better physical-chemical and structural performance. Therefore, these hydrogels should be further investigated regarding their potential in medical and pharmaceutical applications, especially in wound healing. (AU)

• Processo FAPESP: 20/15774-5 - Desenvolvimento de métodos de extração, separação e análise bidimensional de compostos fenólicos em produtos naturais
• Beneficiário: Juliane Viganó
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 20/08212-0 - Desenvolvimento de dispositivos baseados em amido extraído da mandioca para liberação controlada de bioativos produzidos por fungos amazônicos
• Beneficiário: Mariana Agostini de Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/07575-2 - Aplicação de tecnologias de alta pressão para obtenção de bioprodutos: montagem de um equipamento multipropósito e desenvolvimento de processos para o barbatimão
• Beneficiário: Priscilla Carvalho Veggi
• Modalidade de apoio: Auxílio à Pesquisa - Regular