Neuroplastic alterations in cannabinoid receptors type 1 (CB1) in animal models of epileptic seizures

Autor(es)

Lazarini-Lopes, Willian ; Silva-Cardoso, Gleice Kelli

• Tipo de documento: Artigo Científico
• Fonte: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 137, p. 17-pg., 2022-05-05.

Resumo

Currently, there is an urgent need to better comprehend neuroplastic alterations in cannabinoid receptors type 1 (CB1) and to understand the biological meaning of these alterations in epileptic disorders. The present study reviewed neuroplastic changes in CB1 distribution, expression, and functionality in animal models of epileptic seizures. Neuroplastic alterations in CB1 were consistently observed in chemical, genetic, electrical, and febrile seizure models. Most studies assessed changes in hippocampal and cortical CB1, while thalamic, hypothalamic, and brainstem nuclei were rarely investigated. Additionally, the relationship between CB1 alteration and the control of brain excitability through modulation of specific neuronal networks, such as striatonigral, nigrotectal and thalamocortical pathways, and inhibitory projections to hippocampal pyramidal neurons, were all presented and discussed in the present review. Neuroplastic alterations in CB1 detected in animal models of epilepsy may reflect two different scenarios: (1) endogenous adaptations aimed to control neuronal hyperexcitability in epilepsy or (2) pathological alterations that facilitate neuronal hyperexcitability. Additionally, a better comprehension of neuroplastic and functional alterations in CB1 can improve pharmacological therapies for epilepsies and their comorbidities. (AU)

• Processo FAPESP: 19/05957-8 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e HUF-101 em modelos experimentais in vivo e in vitro
• Beneficiário: Norberto Garcia Cairasco
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/06877-5 - Tratamento sistêmico com canabidiol em modelo de dor neuropática: avaliação dos componentes sensorial-discriminativo e emocional-motivacional da sensibilidade dolorosa
• Beneficiário: Gleice Kelli Ribeiro da Silva Cardoso
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/14198-3 - Epilepsias e comorbidades neuropsiquiátricas: caracterização dos efeitos do tratamento com canabidiol e huf-101 em modelos experimentais in vivo e in vitro
• Beneficiário: Willian Lazarini Lopes
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico