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Intermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intake

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Oliveira, Luciana da Costa ; Morais, Gustavo Paroschi ; de Oliveira, Franciane Pereira ; Mata, Milene Montavoni ; Veras, Allice Santos Cruz ; da Rocha, Alisson Luiz ; Elias, Lucila Leico Kagohara ; Teixeira, Giovana Rampazzo ; de Moraes, Camila ; Cintra, Dennys E. ; Ropelle, Eduardo R. ; de Moura, Leandro P. ; Pauli, Jose R. ; de Freitas, Ellen C. ; Rorato, Rodrigo ; da Silva, Adelino Sanchez R.
Número total de Autores: 16
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 119, p. 12-pg., 2023-05-29.
Resumo

High-fat diet consumption causes hypothalamic inflammation, dysregulating the leptin pathway, which, in turn, compromises the modulation of hy-pothalamic neuronal activities and predisposes obesity development. Intermittent fasting (IF) and exercise training (ET) have been demonstrated as efficient interventions to modulate hypothalamic inflammation and neuronal activity. However, no studies have evaluated whether combining these interventions could induce better results in reestablishing hypothalamic homeostasis disrupted by high-fat diet intake. The 8-week-old male C57BL/6 mice were randomly assigned into 2 groups: sedentary mice fed a standard diet (CT), and sedentary mice fed a high-fat diet (HF). After 8 weeks of an HF diet, part of the HF group (now 16 weeks old) was randomly subjected to different interventions for 6 weeks: HF-IF = HF diet mice submitted to IF; HF-T = HF diet mice sub-mitted to ET; HF-IFT = HF diet mice submitted to IF and ET. All interventions decreased the body weight gain induced by high-fat diet intake, associated with reduced calorie consumption in week 14. Only the HF-IFT group presented improved serum insulin, leptin, resistin, and Tnf-alpha levels concomitantly with decreased hypothalamic inflammation. The HF-IFT group also demonstrated increased Pomc mRNA expression associated with enhanced pSTAT3 ex-pression in the hypothalamic arcuate and ventromedial hypothalamic nuclei. Our data indicate that the beneficial effects of the combination of IF and ET on energy homeostasis are associated with increased leptin sensitivity in the hypothalamic arcuate nucleus and ventromedial hypothalamic nucleus, which is likely due to an improvement in hypothalamic inflammatory pathways in these nuclei.& COPY; 2023 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 16/17968-6 - Circuitaria e fenótipos neuronais hipotalâmicos envolvidos no acoplamento da atividade do eixo hipotálamo-hipófise-adrenal às alterações da homeostase energética
Beneficiário:Rodrigo César Rorato
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 20/08192-0 - Respostas da via da autofagia no hipotálamo de camundongos obesos submetidos ao jejum intermitente associado ao treinamento físico
Beneficiário:Adelino Sanchez Ramos da Silva
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 19/17532-1 - Exercício físico como estratégia não farmacológica na prevenção e tratamento da Doença de Alzheimer
Beneficiário:Gustavo Paroschi Morais
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 17/25492-4 - Efeitos da combinação do jejum intermitente com o exercício físico sobre a via autofágica hipotalâmica em camundongos obesos
Beneficiário:Luciana da Costa Oliveira
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 19/21709-4 - Implicações do desequilíbrio mitonuclear e da UPRmt em neurônios hipotalâmicos na gênese da Obesidade
Beneficiário:Eduardo Rochete Ropelle
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 21/06291-3 - EMU concedido no processo 2019/11820-5: ChemiDoc Imaging System e acessórios
Beneficiário:Adelino Sanchez Ramos da Silva
Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários