| Texto completo | |
| Autor(es): Mostrar menos - |
dos Santos, Raisa Magno
;
Miyamoto, Josiane Erica
;
Siqueira, Beatriz Piatezzi
;
Araujo, Thiago Reis
;
Vettorazzi, Jean Franciesco
;
Menta, Penelope Lacrisio Reis
;
Denom, Jessica
;
Latorraca, Marcia Queiroz
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Cruciani-Guglielmacci, Celine
;
Carneiro, Everardo Magalhaes
;
Torsoni, Adriana
;
Torsoni, Marcio
;
Badan, Ana Paula
;
Magnan, Christophe
;
Le Stunff, Herve
;
Ignacio-Souza, Leticia
;
Milanski, Marciane
Número total de Autores: 17
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| Tipo de documento: | Artigo Científico |
| Fonte: | Food Research International; v. 177, p. 12-pg., 2023-12-21. |
| Resumo | |
Interesterified fats have been used to replace trans-fat in ultra-processed foods. However, their metabolic effects are not completely understood. Hence, this study aimed to investigate the effects related to glucose homeostasis in response to interesterified palm oil or refined palm oil intake. Four-week-old male Swiss mice were randomly divided into four experimental groups and fed the following diets for 8 weeks: a normocaloric and normolipidic diet containing refined palm oil (PO group) or interesterified palm oil (IPO group); a hypercaloric and high-fat diet containing refined PO (POHF group) or interesterified PO (IPOHF group). Metabolic parameters related to body mass, adiposity and food consumption showed no significant differences. As for glucose homeostasis parameters, interesterified palm oil diets (IPO and IPOHF) resulted in higher glucose intolerance than unmodified palm oil diets (PO and POHF). Euglycemic-hyperinsulinemic clamp assessment showed a higher endogenous glucose production in the IPO group compared with the PO group. Moreover, the IPO group showed significantly lower p-AKT protein content (in the muscle and liver tissues) when compared with the PO group. Analysis of glucose-stimulated static insulin secretion (11.1 mmol/L glucose) in isolated pancreatic islets showed a higher insulin secretion in animals fed interesterified fat diets (IPO and IPOHF) than in those fed with palm oil (PO and POHF). Interesterified palm oil, including in normolipidic diets, can impair insulin signaling in peripheral tissues and increase insulin secretion by beta-cells, characterizing insulin resistance in mice. (AU) | |
| Processo FAPESP: | 20/16040-5 - Efeitos metabólicos da gordura interesterificada e seus metabólitos na homeostasia glicêmica e lipídica |
| Beneficiário: | Josiane Érica Miyamoto |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 16/24768-3 - Avaliação de parâmetros metabólicos em resposta à ingestão de gordura interesterificada em animais experimentais: mecanismos moleculares envolvidos |
| Beneficiário: | Josiane Érica Miyamoto |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 19/26538-3 - Avaliação da permeabilidade e imunomodulação da mucosa intestinal em animais alimentados com dieta rica em gordura interesterificada |
| Beneficiário: | Marciane Milanski Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |