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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inflammatory markers are associated with inhibitory avoidance memory deficit induced by sleep deprivation in rats

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Autor(es):
Esumi, L. A. [1] ; Palma, B. D. [1] ; Gomes, V. L. [1] ; Tufik, S. [1] ; Hipolide, D. C. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 221, n. 1, p. 7-12, AUG 1 2011.
Citações Web of Science: 8
Resumo

Sleep deprivation (SD) causes detrimental effects to the body, such as memory impairment and weight loss. SD also changes the concentration of inflammatory mediators such as cytokines, which, in turn, can affect cognitive functioning. Thus, the objective of this study was to investigate the involvement of these inflammatory mediators in inhibitory avoidance memory deficit in sleep-deprived rats. Male Wistar rats were deprived of sleep by the modified multiple platform method for 96 h, while their respective controls remained in their housing cages. To assess memory after SD, all animals underwent training, followed by the inhibitory avoidance task test 24 h later. Also, the weight of each animal was recorded daily. In the first experiment, animals received an acute administration of lipopolysaccharide (LPS, 50 or 75 mu g/kg i.p.) 3 h before the inhibitory avoidance training. In the experiment 2, the animals received acute or chronic administration of anti-IL-6 antibody (Ab, 2 mu g/kg i.p.). The acute administration was performed 3 h before the inhibitory avoidance training, while the chronic treatment administrations were performed daily during the SD period. The 75 mu g/kg dose of LPS, but not the 50 mu g/kg dose, caused a significant attenuation of memory impairment in the sleep-deprived animals. Although the treatments with the anti-IL-6 Ab did not produce any significant changes in cognitive performance, the Ab attenuated weight loss in sleep-deprived animals. Taken together, these results suggest the involvement of inflammatory mediators in the modulation of memory deficit and weight loss that are observed in sleep-deprived rats. (C) 2011 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 08/51656-5 - Avaliação da participação de mediadores inflamatórios no prejuízo de memória e perda de peso de ratos privados de sono
Beneficiário:Lia Assae Esumi
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs