| Texto completo | |
| Autor(es): |
Borsoi, Felipe Tecchio
;
Arruda, Henrique Silvano
;
Reguengo, Livia Mateus
;
Numa, Iramaia Angelica Neri
;
Pastore, Glaucia Maria
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Food Chemistry; v. 483, p. 17-pg., 2025-08-15. |
| Resumo | |
This study aimed to evaluate the influence of gastrointestinal digestion on the phytochemical profile, phenolic compounds, antioxidant capacity, and sugar content in the ara & ccedil;a<acute accent>-boi extract. Additionally, molecular docking of target proteins and ADMET analysis were performed using the major compound of ara & ccedil;a<acute accent>-boi extract after gastrointestinal digestion. UHPLC-Q-Orbitrap-MS/MS analyses revealed 100 compounds identified, and after gastrointestinal digestion, only 59 compounds were identified. Gastrointestinal digestion had a significant impact on phenolic compounds and sugar content. The extract showed an increase in antioxidant capacity in the ABTS center dot+ assay, while it decreased in the DPPH, FRAP, and ORAC assays after gastrointestinal digestion. The in silico study showed that trans-cinnamic acid interacts with target proteins such as NF-kappa B, IL-1 beta, and PI3K and that it has a promising pharmacokinetic profile. These findings emphasize the importance of further investigating the effects of the extract in different physiological contexts and its potential applications. (AU) | |
| Processo FAPESP: | 20/08761-4 - Caracterização química de compostos bioativos de plantas alimentícias não convencionais (panc) para o desenvolvimento de produtos com apelo funcional |
| Beneficiário: | Glaucia Maria Pastore |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/25048-2 - Bioacessibilidade de casca de jabuticaba em modelo colônico dinâmico e efeito anti-inflamatório em macrófagos |
| Beneficiário: | Livia Mateus Reguengo |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |