Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma

Autor(es)

Brassesco, Maria Sol ^[1] ; Valera, Elvis Terci ^[1] ; Bonilha, Thais Alcantara ^[1] ; Scrideli, Carlos Alberto ^[1] ; de Oliveira, Jaqueline Carvalho ^[2] ; Pezuk, Julia Alejandra ^[2] ; Barros Silva, Gyl Eanes ^[3] ; Costa, Roberto Silva ^[3] ; Tone, Luiz Gonzaga ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pediat, Div Pediat Oncol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Genet, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CANCER GENETICS; v. 204, n. 2, p. 108-110, FEB 2011.
• Citações Web of Science: 10

Resumo

Xp11.2 translocation-associated renal cell carcinoma (RCC) is a rare tumor that accounts for at least one-third of childhood RCC. Different reports have emphasized that previous radio/chemotherapy might be involved in its pathogenesis. We describe a child who developed a t(X;1) (p11.2;p34) associated RCC after previous treatment for genitourinary rhabdomyosarcoma in infancy. The presence of the PSF-TFE3 fusion has only been described in a very limited number of cases. Our report expands the spectrum of tumors in which RCC can arise in the pediatric age group after chemotherapy. (AU)

• Processo FAPESP: 07/54236-4 - Analise do perfil genomico em neoplasias da infancia atraves da hibridizacao genomica comparativa.
• Beneficiário: Luiz Gonzaga Tone
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/04827-3 - Análise de aneuploidias por hibridação genômica comparativa (CGH) em pacientes pediátricos portadores de leucemia linfóide aguda
• Beneficiário: María Sol Brassesco Annichini
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado