Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma

Author(s)

Brassesco, Maria Sol ^[1] ; Valera, Elvis Terci ^[1] ; Bonilha, Thais Alcantara ^[1] ; Scrideli, Carlos Alberto ^[1] ; de Oliveira, Jaqueline Carvalho ^[2] ; Pezuk, Julia Alejandra ^[2] ; Barros Silva, Gyl Eanes ^[3] ; Costa, Roberto Silva ^[3] ; Tone, Luiz Gonzaga ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Pediat, Div Pediat Oncol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Genet, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, Sao Paulo - Brazil

• Document type: Journal article
• Source: CANCER GENETICS; v. 204, n. 2, p. 108-110, FEB 2011.
• Web of Science Citations: 10

Abstract

Xp11.2 translocation-associated renal cell carcinoma (RCC) is a rare tumor that accounts for at least one-third of childhood RCC. Different reports have emphasized that previous radio/chemotherapy might be involved in its pathogenesis. We describe a child who developed a t(X;1) (p11.2;p34) associated RCC after previous treatment for genitourinary rhabdomyosarcoma in infancy. The presence of the PSF-TFE3 fusion has only been described in a very limited number of cases. Our report expands the spectrum of tumors in which RCC can arise in the pediatric age group after chemotherapy. (AU)

• FAPESP's process: 06/04827-3 - Analysis of aneuploidies by comparative genomic hybridization (CGH) in pediatric patients with acute lymphoid leukemia
• Grantee: María Sol Brassesco Annichini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral