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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Mechanism of Fluoride Dentifrice Effect on Enamel Demineralization

Texto completo
Autor(es):
Tenuta, L. M. A. [1] ; Zamataro, C. B. ; Del Bel Cury, A. A. ; Tabchoury, C. P. M. ; Cury, J. A.
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Fac Odontol Piracicaba, BR-13414903 Piracicaba, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Caries Research; v. 43, n. 4, p. 278-285, 2009.
Citações Web of Science: 33
Resumo

Although the anticaries effect of fluoride (F) dentifrices is clearly established, the relative importance of F taken up by dental plaque not removed by brushing and of F products (CaF(2)-like) formed on totally cleaned enamel for the subsequent inhibition of demineralization is not known. Both effects were evaluated using conventional (1,100 mu g F/g) and low-F concentration (500 mu g F/g) dentifrices in a randomized, crossover, double-blind in situ study. Enamel blocks not treated or pretreated with the dentifrices to form CaF(2)-like deposits were mounted in palatal appliances in contact with a Streptococcus mutans test plaque. Volunteers brushed with non-F (negative control), low-F or conventional dentifrices and inserted the appliance in the mouth. F concentration in the fluid and solid phases of the test plaque was determined after 30 min, and a rinse with 20% sucrose solution was performed. After additional 45 min, plaque was collected and the loss of surface hardness at different test-plaque depths was measured. CaF(2)-like deposition on enamel and F taken up by plaque due to the use of F dentifrices were able to significantly increase F concentration in the fluid phase of the test plaque, but only the latter significantly reduced the loss of hardness because of the 20-30 times higher F concentration. Also, significant differences between the low-F and conventional dentifrices were observed for F on enamel, in plaque and on the subsequent loss of hardness. The results suggest that uptake of F by dental plaque not removed by brushing may be the main cause of the anticaries effect of F dentifrices. Copyright (C) 2009 S. Karger AG, Basel (AU)

Processo FAPESP: 06/01193-3 - Dentifrício de baixa concentração de fluoreto e a disponibilização de íons minerais no fluido do biofilme
Beneficiário:Jaime Aparecido Cury
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 05/04703-0 - Consolidação da análise do fluido do biofilme dental em pesquisas do Laboratório de Bioquímica Oral da FOP-UNICAMP
Beneficiário:Livia Maria Andaló Tenuta
Linha de fomento: Bolsas no Brasil - Pós-Doutorado