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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

DNA and histone methylation in gastric carcinogenesis

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Autor(es):
Calcagno, Danielle Queiroz [1] ; Gigek, Carolina Oliveira [1] ; Chen, Elizabeth Suchi [1] ; Burbano, Rommel Rodriguez [2] ; Cardoso Smith, Marilia de Arruda [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, BR-04023900 Sao Paulo - Brazil
[2] Fed Univ Para, Lab Human Cytogenet, Inst Biol Sci, BR-66075110 Belem, Para - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: WORLD JOURNAL OF GASTROENTEROLOGY; v. 19, n. 8, p. 1182-1192, FEB 28 2013.
Citações Web of Science: 54
Resumo

Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. (C) 2013 Baishideng. All rights reserved. (AU)

Processo FAPESP: 10/11174-1 - Avaliação genética e epigenética no câncer gástrico
Beneficiário:Danielle Queiroz Calcagno
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 09/07145-9 - Aspectos genéticos e epigenéticos na carcinogênese gástrica
Beneficiário:Marilia de Arruda Cardoso Smith
Linha de fomento: Auxílio à Pesquisa - Temático