Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns

Autor(es)

Borelli, Karina G. ^{[1, 2, 3]} ; Albrechet-Souza, Lucas ^{[1, 2]} ; Fedoce, Alessandra G. ^[4] ; Fabri, Denise S. ^[4] ; Resstel, Leonardo B. ^[4] ; Brandao, Marcus L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Inst Neurociencias & Comportamento, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Neuropsicofarmacol, Ribeirao Preto, SP - Brazil

^[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Nucleo Cognicao & Sistemas Complexos, Santo Andre, SP - Brazil

^[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, BR-14049 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Hormones and Behavior; v. 63, n. 5, p. 791-799, MAY 2013.
• Citações Web of Science: 8

Resumo

The periaqueductal gray (PAG) columns have been implicated in controlling stress responses through corticotropin-releasing factor (CRF), which is a neuropeptide with a prominent role in the etiology of fear-and anxiety-related psychopathologies. Several studies have investigated the involvement of dorsal FAG (dPAG) CRF mechanisms in models of unconditioned fear. However, less is known about the role of this neurotransmission in the expression of conditioned fear memories in the dPAG and ventrolateral FAG (vlPAG) columns. We assessed the effects of ovine CRF (oCRF 0.25 and 1.0 mu g/0.2 mu L) locally administered into the dPAG and vlPAG on behavioral (fear-potentiated startle and freezing) and autonomic (arterial pressure and heart rate) responses in rats subjected to contextual fear conditioning. The lower dose injected into the columns promoted proaversive effects, enhanced contextual freezing, increased the blood pressure and heart rate and decreased tail temperature. The lower dose of oCRF into the vlPAG, but not into the dPAG, produced a pronounced enhancement of the fear-potentiated startle response. The results imply that the FAG is a heterogeneous structure that is involved in the coordination of distinct behaviors and autonomic control, suggest PAG involvement in the expression of contextual fear memory as well as implicate the CRF as an important modulator of the neural substrates of fear in the PAG. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 11/07332-3 - Estudo do envolvimento do hipocampo dorsal de ratos nas respostas comportamentais e autonômicas associadas a reações de defesa: uma possível via receptores NMDA/óxido nítrico e endocanabinóides
• Beneficiário: Leonardo Resstel Barbosa Moraes
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/00041-3 - Neurobiologia do estresse: a interface sensório-motora
• Beneficiário: Marcus Lira Brandão
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/09300-4 - O sistema noradrenérgico presente no núcleo leito da estria terminal modula a resposta emocional condicionada contextual: uma possível interação com o CRF e as neurotransmissões glutamatérgica e nitrérgica
• Beneficiário: Leonardo Resstel Barbosa Moraes
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/20762-7 - Avaliação da participação do estresse oxidativo/nitrosativo induzidos pelo estresse de restrição na modulação da resposta emocional condicionada
• Beneficiário: Alessandra das Graças Fedoce
• Linha de fomento: Bolsas no Brasil - Doutorado