Strategies for delivering local anesthetics to the skin: focus on liposomes, solid lipid nanoparticles, hydrogels and patches

Autor(es)

de Araujo, Daniele R. ^[1] ; da Silva, Deyse C. ^[1] ; Barbosa, Raquel M. ^[2] ; Franz-Montan, Michelle ^[2] ; Cereda, Cintia M. S. ^[2] ; Padula, Cristina ^[3] ; Santi, Patrizia ^[3] ; de Paula, Eneida ^[2]

Afiliação do(s) autor(es)

^[1] ABC Fed Univ, Nat & Human Sci Ctr, BR-09210580 Santo Andre - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Biochem, BR-13083862 Campinas, SP - Brazil

^[3] Univ Parma, I-43100 Parma - Italy

• Tipo de documento: Artigo de Revisão
• Fonte: Expert Opinion on Drug Delivery; v. 10, n. 11, p. 1551-1563, NOV 2013.
• Citações Web of Science: 31

Resumo

Introduction: Dermal and transdermal drug delivery systems offer the possibility to control the release of the drug for an extended period of time. In particular, skin-delivery of local anesthetics (LA) is one of the most important strategies to increase the local drug concentration and to reduce systemic adverse reactions. Areas covered: During the development phase of new formulations for skin-delivery of LA one should consider a set of desirable features such providing suitable adhesion, easy application/removal and also to be biocompatible, biodegradable and non-toxic. This review emphasizes the main strategies for skin-delivery of LA considering those features in relation to the composition of the delivery systems described. The topics highlight the relationships between physico-chemical studies and pharmaceutical applications for liposomes and solid lipid nanoparticles as well as the formulation and clinical applications for hydrogels and patches. Expert opinion: The development of LA skin-delivery systems using hydrogels and different permeation enhancers, liposomes or lipid nanoparticles (as isolated carrier systems or as their dispersion in a gel-base) and patches have been explored as alternatives to commercial formulations, modifying the release rate of LA, increasing bioadhesive properties and reducing toxicity, resulting in an improved therapeutic efficacy. This review should provide to the reader a special emphasis on four delivery-systems, comprising the group of liposomes and lipid nanoparticles, hydrogels and patches technologies looking forward their application for skin anesthesia. (AU)

• Processo FAPESP: 06/00121-9 - Novas formulações de anestésicos locais de liberação controlada: do desenvolvimento ao teste clínico odontológico
• Beneficiário: Eneida de Paula
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 11/05581-6 - Hidrogéis poliméricos termorreversíveis e sistemas lipossomais para liberaçao transdérmica de lidocaína
• Beneficiário: Deyse Cardoso da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 10/11475-1 - Desenvolvimento e avaliação farmacológica de sistemas de liberação modificada contendo tramadol em hidrogéis termorreversíveis para o tratamento da dor
• Beneficiário: Daniele Ribeiro de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Regular