Lymphocyte activation in silica-exposed workers

Autor(es)

Rocha-Parise, Michelle ^[1] ; Santos, Leonilda M. B. ^[2] ; Damoiseaux, Jan G. M. C. ^[3] ; Bagatin, Ericson ^[4] ; Lido, Alessandro V. ^[4] ; Torello, Cristiane Okuda ^[1] ; Cohen Tervaert, Jan W. ^{[5, 6]} ; Queiroz, Mary L. S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, State Univ Campinas, Fac Med Sci, FCM, Dept Pharmacol & Hemoctr, BR-13083878 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, State Univ Campinas, Inst Biol, Dept Genet Neuroimmunol Unit Evolut & Bioagents, BR-13083878 Campinas, SP - Brazil

^[3] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht - Netherlands

^[4] Univ Estadual Campinas, State Univ Campinas, Fac Med Sci, FCM, Dept Prevent & Social Med, Occupat Med Area, BR-13083878 Campinas, SP - Brazil

^[5] Maastricht Univ, Maastricht - Netherlands

^[6] St Franciscus Gasthuis, Rotterdam - Netherlands

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH; v. 217, n. 4-5, p. 586-591, APR-MAY 2014.
• Citações Web of Science: 10

Resumo

Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. (C) 2013 Elsevier GmbH. All rights reserved. (AU)

• Processo FAPESP: 01/13823-8 - Alterações imunotoxicológicas e estresse oxidativo de eritrócitos e neutrófilos em trabalhadores expostos à silica
• Beneficiário: Mary Luci de Souza Queiroz
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/53901-4 - Investigação da autoimunidade em associação à exposição ocupacional à sílica
• Beneficiário: Michelle Rocha Parise
• Modalidade de apoio: Bolsas no Brasil - Doutorado