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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lymphocyte activation in silica-exposed workers

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Author(s):
Rocha-Parise, Michelle [1] ; Santos, Leonilda M. B. [2] ; Damoiseaux, Jan G. M. C. [3] ; Bagatin, Ericson [4] ; Lido, Alessandro V. [4] ; Torello, Cristiane Okuda [1] ; Cohen Tervaert, Jan W. [5, 6] ; Queiroz, Mary L. S. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, State Univ Campinas, Fac Med Sci, FCM, Dept Pharmacol & Hemoctr, BR-13083878 Campinas, SP - Brazil
[2] Univ Estadual Campinas, State Univ Campinas, Inst Biol, Dept Genet Neuroimmunol Unit Evolut & Bioagents, BR-13083878 Campinas, SP - Brazil
[3] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht - Netherlands
[4] Univ Estadual Campinas, State Univ Campinas, Fac Med Sci, FCM, Dept Prevent & Social Med, Occupat Med Area, BR-13083878 Campinas, SP - Brazil
[5] Maastricht Univ, Maastricht - Netherlands
[6] St Franciscus Gasthuis, Rotterdam - Netherlands
Total Affiliations: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH; v. 217, n. 4-5, p. 586-591, APR-MAY 2014.
Web of Science Citations: 10
Abstract

Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. (C) 2013 Elsevier GmbH. All rights reserved. (AU)

FAPESP's process: 01/13823-8 - Immunotoxicological changes and antioxidant system in erytrocytes and neutrophils in silica-exposed workers
Grantee:Mary Luci de Souza Queiroz
Support Opportunities: Research Projects - Thematic Grants