Molecular Evolution of Zika Virus during Its Emergence in the 20th Century

Autor(es)

Faye, Oumar ^[1] ; Freire, Caio C. M. ^[2] ; Iamarino, Atila ^[2] ; Faye, Ousmane ^[1] ; de Oliveira, Juliana Velasco C. ^[2] ; Diallo, Mawlouth ^[1] ; Zanotto, Paolo M. A. ^[2] ; Sall, Amadou Alpha ^[1]

Afiliação do(s) autor(es)

^[1] Inst Pasteur, Dakar - Senegal

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS Neglected Tropical Diseases; v. 8, n. 1 JAN 2014.
• Citações Web of Science: 373

Resumo

Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (http://www.pasteur.fr/recherche/banques/CRORA/) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Cote d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20th century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector. (AU)

• Processo FAPESP: 10/19341-4 - Caracterização biológica de recombinantes naturais e artificiais entre os subtipos B e F de HIV-1
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 00/04205-6 - Projeto VIRGEN - Viral Genetic Diversity Network (VGDN)
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/04818-5 - Evolução e filodinâmica dos recombinantes BF de HIV-1 da América do Sul
• Beneficiário: Atila Iamarino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado