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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular Evolution of Zika Virus during Its Emergence in the 20th Century

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Author(s):
Faye, Oumar [1] ; Freire, Caio C. M. [2] ; Iamarino, Atila [2] ; Faye, Ousmane [1] ; de Oliveira, Juliana Velasco C. [2] ; Diallo, Mawlouth [1] ; Zanotto, Paolo M. A. [2] ; Sall, Amadou Alpha [1]
Total Authors: 8
Affiliation:
[1] Inst Pasteur, Dakar - Senegal
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 8, n. 1 JAN 2014.
Web of Science Citations: 373
Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (http://www.pasteur.fr/recherche/banques/CRORA/) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Cote d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20th century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector. (AU)

FAPESP's process: 10/19341-4 - Biological characterization of natural and artificial HIV-1 recombinants between subtypes B and F
Grantee:Paolo Marinho de Andrade Zanotto
Support Opportunities: Regular Research Grants
FAPESP's process: 12/04818-5 - Evolution and phyloynamics of HIV-1 BF recombinants from South America
Grantee:Atila Iamarino
Support Opportunities: Scholarships in Brazil - Post-Doctoral