Scholarship 24/17895-5 - Diversidade genética, Filogeografia - BV FAPESP
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Phylodynamics, and Evolution of Influenza A/H1N1pdm09 in Brazil: Integrating Genetic, Epidemiological, and Temporal Data (2009-2024)

Grant number: 24/17895-5
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Start date until: March 01, 2025
End date until: June 01, 2025
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Maria Carolina Quartim Barbosa Elias Sabbaga
Grantee:Isabela Carvalho Brcko
Supervisor: Marta Giovanetti
Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Institution abroad: Università Campus Bio-Medico Di Roma, Italy  
Associated to the scholarship:23/07688-0 - Comparative phylogenetics, phylogeography and epidemiology applied in understanding the evolution of COVID-19, Influenza, and Dengue viruses in Brazil, BP.PD

Abstract

This project aims to conduct a comprehensive phylodynamic analysis of the Influenza A/H1N1pdm09 virus in Brazil, spanning from 2009 to 2024. Influenza A viruses are significant public health threats, causing severe respiratory infections and resulting in substantial morbidity and mortality worldwide. The emergence of the A/H1N1pdm09 strain marked the first human influenza pandemic of the 21st century, with distinct epidemiological patterns observed in Brazil compared to other countries. Collaborating with Dr. Marta Giovanetti, a prominent researcher with extensive expertise in this field, strengthens the justification for the intention of conducting the internship abroad. This collaboration is particularly important given the significant deficiencies noted in the phylogeography of the Influenza virus in Brazil. Furthermore, this project is aligned with the CeVIVAS (Center for Viral Surveillance and Serological Assessment) initiative, led by the Butantan Institute, which aims to identify viral diversity and analyze the transmission and evolutionary dynamics of viruses through systematic sample collection across all macroregions of the country. Leveraging whole-genome sequencing and advanced phylogenetic methodologies, this research will elucidate the evolutionary dynamics and transmission patterns of A/H1N1pdm09 across Brazil's diverse climatic regions. By integrating genetic, epidemiological, and temporal data, the study intends to uncover the historical and ongoing impacts of the virus, revealing evolutionary and transmission patterns within and between Brazil's macroregions. This analysis will not only enhance our understanding of the virus's adaptation strategies but also provide insights into its transmission intensity and heterogeneity among populations. The findings will be instrumental in informing vaccine composition and vaccination strategies, ultimately contributing to better public health responses to influenza outbreaks in Brazil. Through this initiative, the project seeks to identify key factors influencing viral persistence and genetic diversity, offering valuable perspectives on Influenza epidemiology in the context of Brazil's unique ecological landscape.

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