Update on infections and vaccinations in systemic lupus erythematosus and Sjogren's syndrome

Autor(es)

Pasoto, Sandra G. ^[1] ; Ribeiro, Ana C. M. ^[1] ; Bonfa, Eloisa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CURRENT OPINION IN RHEUMATOLOGY; v. 26, n. 5, p. 528-537, SEP 2014.
• Citações Web of Science: 17

Resumo

Purpose of review To provide an update on infections in systemic lupus erythematosus (SLE) and Sjogren's syndrome, particularly addressing their role as triggers of autoimmunity, their impact on mortality, the main microorganisms, the approaches to differential diagnosis with disease flares and recommendations for vaccination. Recent findings New mechanisms for autoimmunity triggered by Epstein-Barr virus and human commensal microbiota have been described. The increased risk for tuberculosis was recently demonstrated for the first time in Sjogren's syndrome. C-reactive protein was reported to be a more sensitive and specific marker for bacterial infections in SLE than procalcitonin and phagocyte-specific S100A8/A9 protein. Inactivated vaccines are well tolerated and efficacy was demonstrated for influenza vaccine. Immunogenicity is generally reduced but adequate in SLE. Prednisone or immunosuppressants are associated with decreased vaccine serological response, whereas hydroxicloroquine seems to improve vaccine immunogenicity. Other infection-preventive measures for these diseases include antimalarials and prophylaxis for tuberculosis or Pneumocystis jirovecii. Summary Advances in the role of infectious agents as triggers for SLE and Sjogren's syndrome have provided new insights into disease development. Knowledge on vaccine immunogenicity, safety and efficacy has improved with evidence of a generally reduced but adequate response for inactivated vaccines in SLE. Other preventive measures comprise infection prophylaxis and antimalarials. (AU)

• Processo FAPESP: 10/10013-4 - Autoanticorpos séricos da síndrome de Sjögren primária: estudo das associações clínicas e das possíveis correlações com anticorpos dirigidos a antígenos virais: vírus Epstein-Barr e Human T Leukemia virus 1
• Beneficiário: Sandra Gofinet Pasoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/51897-5 - Terapia anti-TNF em doenças auto-imunes reumatológicas: abordagem de aspectos peculiares
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático