Relationship between gut hormones and glucose homeostasis after bariatric surgery

Autor(es)

Sala, Priscila Campos ^[1] ; Torrinhas, Raquel Susana ^[1] ; Giannella-Neto, Daniel ^[2] ; Waitzberg, Dan Linetzky ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Gastroenterol, Sch Med, Digest Surg Discipline LIM 35, BR-01246903 Sao Paulo - Brazil

^[2] Univ Nove de Julho, Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: DIABETOLOGY & METABOLIC SYNDROME; v. 6, AUG 16 2014.
• Citações Web of Science: 18

Resumo

Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective treatment for severely obese patients. After bariatric surgery, T2D patients have shown a significant improvement in glycemic control, even before substantial weight loss and often discontinuation of medication for diabetes control. A central role for enteroendocrine cells from the epithelium of the gastrointestinal tract has been speculated in this postoperative phenomenon. These cells produce and secrete polypeptides - gut hormones - that are associated with regulating energy intake and glucose homeostasis through modulation of peripheral target organs, including the endocrine pancreas. This article reviews and discusses the biological actions of the gut hormones ghrelin, cholecystokinin, incretins, enteroglucagon, and Peptide YY, all of which were recently identified as potential candidates for mediators of glycemic control after bariatric surgery. In conclusion, current data reinforce the hypothesis that T2D reversion after bariatric surgery may be related to glycemic homeostasis developed by the intestine. (AU)

• Processo FAPESP: 13/03246-0 - Estudo genômico, proteômico e metabolômico do tecido gastrointestinal de portadores de Diabetes melito tipo 2 após gastroplastia redutora a Y-Roux
• Beneficiário: Priscila Sala Kobal
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 11/09612-3 - Alterações na expressão gênica do tecido gástrico e intestinal de portadores de Diabetes melito tipo 2 submetidos à gastroplastia redutora a Y-Roux
• Beneficiário: Dan Linetzky Waitzberg
• Modalidade de apoio: Auxílio à Pesquisa - Temático